Novel Nanoformulations and Nanosensors for Bioactive Mmolicules of Biomedical Significance
Presented by: Ms Saiqa Muneer
Supervisors:
Dr Emad Kiriakous (Principal)
Dr Nazrul Islam
Prof. Godwin Ayoko
Review Panel:
Chair of the Panel: Prof. Eric Waclawik
Member – Dr. Emad Kiriakous
Member – Dr. Enoch Chan
Abstract:
The synthesis and analysis of bioactive molecules advances our understanding towards biological systems and is fundamental for improvement in drug development. Bioactive molecules is a broad term that defines many composites of diverse origins such as plant and animal origin. They are undergoing an emergent attention in a wide range of applications such as: medicine, plant and animal science, modern pharmacology, cosmetics, food industry, nano and biosciences. Among these compounds, proteins, antibodies and antibiotics, all play vibrant roles in human metabolism and health. Various sensitive and specific analytical techniques have been established for the determination of different bioactive molecules in human body and biological fluids. These analytical techniques include chromatography, enzyme linked immunosorbent assay and spectroscopic method. This report firstly give the introduction and the research background of various formluation development methods for vaious bioactive molecules and the analytical techniques employed to detect the drugs in biological fluids. It outlines the research methodology and research plan. It comprises of the current experimental results till date based on antibody drugs (Infliximab and Adalimumab). It also describes the analytical technique, Surface enhanced Raman spectroscopy [SERS] which is demonstrated to be rapid, specific and most sensitive mode of detection of various bioactive molecules in biological fluids as compared to other industrially accepted techniques. It also describes the prospective future work by extending the studies of SERS detection of antibody drug studies to human cardiac biomarker protein troponin T and I for the rapid detection and early diagnosis of disease in cardiovascular patients. The nanoformulations of antibiotics and protein drugs for enhanced drug delivery. It presents the development of dry powder inhalers as a superior therapy to the injectables which are presumably designed for various unstable drugs in solution forms. Moreover, future timeline for the completion of each stage of the study and the ethical considerations (low risk) of the research are presented in the report.
Details:
| Location: | Z Block, Room Z413, QUT Gardens Point Campus |
| Start Date: | 02/05/2019 [add to calendar] |
| Start Time: | 14:00 |
| End Date: | 02/05/2019 |
| End Time: | 15:00 |