Our Research

Our world-renowned researchers and use novel culture-independent molecular approaches and bioinformatics tools to answer important questions about the role of microbial communities in human and environmental health.

Research Programs


Recent Publications

Probing the eukaryotic microbes of ruminants with a deep-learning classifier and comprehensive protein databases

Yan, Ming, Andersen, Thea O., Pope, Phillip B., Yu, Zhongtang (2025) Probing the eukaryotic microbes of ruminants with a deep-learning classifier and comprehensive protein databases. Genome Research, 35 (2), pp.368-378.
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For long-term sustainable software in bioinformatics

Coelho, Luis Pedro (2024) For long-term sustainable software in bioinformatics. PLoS Computational Biology, 20 (3), pp.Article number: e1011920.
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Nitrate-driven anaerobic oxidation of ethane and butane by bacteria

Wu, Mengxiong, Li, Jie, Lai, Chun-Yu, Leu, Andy, Sun, Shengjie, Gu, Rui, Erler, Dirk V., Liu, Lian, Li, Lin, Tyson, Gene, et al. (2024) Nitrate-driven anaerobic oxidation of ethane and butane by bacteria. The ISME Journal, 18 (1), pp.Article number: wrad011.
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Molecular dynamics simulations support a preference of cyclotide kalata B1 for phosphatidylethanolamine phospholipids

Roseli, Ras Baizureen, Huang, Yen Hua, Henriques, Sónia Troeira, Kaas, Quentin, Craik, David J. (2024) Molecular dynamics simulations support a preference of cyclotide kalata B1 for phosphatidylethanolamine phospholipids. Biochimica et Biophysica Acta - Biomembranes, 1866 (3), pp.Article number: 184268.
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An AI-assisted integrated, scalable, single-cell phenomic-transcriptomic platform to elucidate intratumor heterogeneity against immune response

Tostado, Christopher P., Da Ong, Lucas Xian, Heng, Joel Jia Wei, Miccolis, Carlo, Chia, Shumei, Seow, Justine Jia Wen, Toh, Yi Chin, DasGupta, Ramanuj (2024) An AI-assisted integrated, scalable, single-cell phenomic-transcriptomic platform to elucidate intratumor heterogeneity against immune response. Bioengineering and Translational Medicine, 9 (2), pp.Article number: e10628.
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Functional and evolutionary significance of unknown genes from uncultivated taxa

Rodriguez del Rio, Alvaro, Giner-Lamia, Joaquin, Cantalapiedra, Carlos P., Botas, Jorge, Deng, Ziqi, Hernandez-Plaza, Ana, Munar-Palmer, Marti, Santamaria-Hernando, Saray, Rodriguez-Herva, Jose J., Ruscheweyh, Hans Joachim, et al. (2024) Functional and evolutionary significance of unknown genes from uncultivated taxa. Nature, 626 (7998), pp.377-384.
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Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide

Philippe, Grégoire Jean Baptiste, Huang, Yen Hua, Mittermeier, Anna, Brown, Christopher J., Kaas, Quentin, Ramlan, Siti Radhiah, Wang, Conan K., Lane, David, Loewer, Alexander, Troeira Henriques, Sónia, et al. (2024) Delivery to, and Reactivation of, the p53 Pathway in Cancer Cells Using a Grafted Cyclotide Conjugated with a Cell-Penetrating Peptide. Journal of Medicinal Chemistry, 67 (2), pp.1197-1208.
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Kinetic, electrochemical and spectral characterization of bacterial and archaeal rusticyanins; unexpected stability issues and consequences for applications in biotechnology

Wilson, Liam A., Melville, Jamie N., Pedroso, Marcelo M., Krco, Stefan, Hoelzle, Robert, Zaugg, Julian, Southam, Gordon, Virdis, Bernardino, Evans, Paul, Supper, Jenna, et al. (2024) Kinetic, electrochemical and spectral characterization of bacterial and archaeal rusticyanins; unexpected stability issues and consequences for applications in biotechnology. Journal of Inorganic Biochemistry, 256, pp.Article number: 112539.
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Development of a Probability-Based In Vitro Eye Irritation Screening Platform

Arora, Seep, Goralczyk, Anna, Andra, Sujana, Lim, Soon Yew John, Toh, Yi Chin (2024) Development of a Probability-Based In Vitro Eye Irritation Screening Platform. Bioengineering, 11 (4), pp.Article number: 315.
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A genome-centric view of the role of the Acropora kenti microbiome in coral health and resilience

Messer, Lauren, Bourne, David G., Robbins, Steven J., Clay, Megan, Bell, Sara, McIlroy, Simon, Tyson, Gene (2024) A genome-centric view of the role of the Acropora kenti microbiome in coral health and resilience. Nature Communications, 15 (1), pp.Article number: 2902.
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Other Publications

A full list of CMR research publications can be found on the CMR Google Scholar listing.