Our Research

Our world-renowned researchers and use novel culture-independent molecular approaches and bioinformatics tools to answer important questions about the role of microbial communities in human and environmental health.

Research Programs


Recent Publications

Metagenomic analysis of fecal microbiomes reveals genetic potential for diverse hydrogen management strategies in marsupials

Bowerman, Kate L., Lu, Kenn, McRae, Harley, Volmer, James, Zaugg, Julian, Pope, Phil, HugenHoltz, Philip, Greening, Christopher, Morrison, Mark, Soo, Rochelle M., et al. (2025) Metagenomic analysis of fecal microbiomes reveals genetic potential for diverse hydrogen management strategies in marsupials. mSystems, pp.Article number: e01608-25.

STREAMS guidelines: standards for technical reporting in environmental and host-associated microbiome studies

Kelliher, Julia M., Mirzayi, Chloe, Bordenstein, Sarah R., Oliver, Aaron, Kellogg, Christina A., Hatcher, Eneida L., Berg, Maureen, Baldrian, Petr, Aljumaah, Mashael, Miller, Cassandra Maria Luz, et al. (2025) STREAMS guidelines: standards for technical reporting in environmental and host-associated microbiome studies. Nature Microbiology, 10 (12), pp.3059-3068.
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Metagenomics: a new frontier for routine pathology testing of gastrointestinal pathogens

Angel, Nicola Z., Sullivan, Mitchell J., Alsheikh-Hussain, Areej, Fang, Liang, MacDonald, Samantha, Pribyl, Alena, Wills, Blake, Tyson, Gene W., Hugenholtz, Philip, Parks, Donovan H., et al. (2025) Metagenomics: a new frontier for routine pathology testing of gastrointestinal pathogens. Gut Pathogens, 17, pp.Article number: 4.
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Potential for aerobic hydrocarbon oxidation in archaea

Leu, Andy O., Woodcroft, Ben J., McIlroy, Simon J., Tyson, Gene W. (2025) Potential for aerobic hydrocarbon oxidation in archaea. Nature Communications, 16 (1), pp.Article number: 9188.
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A framework for integrating genomics, microbial traits, and ecosystem biogeochemistry

Li, Zhen, Riley, William J., Marschmann, Gianna L., Karaoz, Ulas, Shirley, Ian A., Wu, Qiong, Bouskill, Nicholas J., Chang, Kuang Yu, Crill, Patrick M., Grant, Robert F., et al. (2025) A framework for integrating genomics, microbial traits, and ecosystem biogeochemistry. Nature Communications, 16 (1), pp.Article number: 2186.
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Structure and assembly of the MmpL5/MmpS5 efflux transporter from Mycobacterium tuberculosis

Xiong, Zhiqi, Yang, Xiaolin, Wang, Shule, Smart, Caitlan J., Sisson, Hazel M., Lin, Zhenli, Hu, Tianyu, Ran, Yuting, Xu, Chuyao, Yang, Xiuna, et al. (2025) Structure and assembly of the MmpL5/MmpS5 efflux transporter from Mycobacterium tuberculosis. Nature Communications, 16, pp.Article number: 4976.
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3D-Printed Unibody Microfluidic Devices for Organ-on-Chip Applications

Ong, Louis Jun Ye, Kasetsirikul, Surasak, Milton, Laura A., Nie, Xiaolei, Eiken, Andrea W., Chirnside, James, Young, Lucy May Gillian, Nordin, Gregory P., Toh, Yi Chin (2025) 3D-Printed Unibody Microfluidic Devices for Organ-on-Chip Applications. Advanced Materials Technologies, 10 (22), pp.Article number: e01056.
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Metabolic capabilities of key rumen microbiota drive methane emissions in cattle

Lai, Wanxin, Alberdi, Antton, Leu, Andy, de Leon, Arturo V P, Kobel, Carl M., Aho, Velma T E, Roehe, Rainer, Pope, Phil B, Hvidsten, Torgeir R (2025) Metabolic capabilities of key rumen microbiota drive methane emissions in cattle. mSystems, 10 (10), pp.Article number: e00601-25 1-7.
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Methanogenesis inhibition remodels microbial fermentation and stimulates acetogenesis in ruminants

Ni, Gaofeng, Wang, Min, Walker, Nicola, Muetzel, Stefan, Schmidt, Oliver, Fischer, André, Stemmler, René T, Leung, Pok Man, Zhang, Xiumin, Li, Qiushuang, et al. (2025) Methanogenesis inhibition remodels microbial fermentation and stimulates acetogenesis in ruminants. Proceedings of the National Academy of Sciences of the United States of America, 122 (41), pp.Article number: e2514823122 e2514823122.
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Microbial matchmakers: Bifidobacterium evolution across animal hosts

Pope, Phil, Tyson, Gene (2025) Microbial matchmakers: Bifidobacterium evolution across animal hosts. Cell Host and Microbe, 33 (9), pp.1468-1470.
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Other Publications

A full list of CMR research publications can be found on the CMR Google Scholar listing.