Our Research

Our world-renowned researchers and use novel culture-independent molecular approaches and bioinformatics tools to answer important questions about the role of microbial communities in human and environmental health.

Research Programs


Recent Publications

A geological timescale for bacterial evolution and oxygen adaptation

Davín, Adrián A., Woodcroft, Ben J., Soo, Rochelle M., Morel, Benoit, Murali, Ranjani, Schrempf, Dominik, Clark, James W., Álvarez-Carretero, Sandra, Boussau, Bastien, Moody, Edmund R.R., et al. (2025) A geological timescale for bacterial evolution and oxygen adaptation. Science, 388 (6742), pp.Article number: eadp1853.
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Comprehensive taxonomic identification of microbial species in metagenomic data using SingleM and Sandpiper

Woodcroft, Ben J., Aroney, Samuel T. N., Zhao, Rossen, Cunningham, Mitchell, Mitchell, Joshua A. M., Nurdiansyah, Rizky, Blackall, Linda, Tyson, Gene W. (2025) Comprehensive taxonomic identification of microbial species in metagenomic data using SingleM and Sandpiper. Nature Biotechnology.
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Simulating big mechanically-active culture systems (BigMACS) using paired biomechanics-histology FEA modelling to derive mechanobiology design relationships

Schoenborn, Sabrina, Yuan, Mingyang, Fell, Cody A., Liu, Chuanhai, Fletcher, David F., Priola, Selene, Chan, Hon Fai, Woodruff, Mia, Li, Zhiyong, Toh, Yi Chin, et al. (2025) Simulating big mechanically-active culture systems (BigMACS) using paired biomechanics-histology FEA modelling to derive mechanobiology design relationships. Biofabrication, 17 (3), pp.Article number: 035006.
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International Symposium on Ruminant Physiology: Current perspective on rumen microbial ecology to improve fiber digestibility

Firkins, J. L., Henderson, E. L., Duan, H., Pope, P. B. (2025) International Symposium on Ruminant Physiology: Current perspective on rumen microbial ecology to improve fiber digestibility. Journal of Dairy Science, 108 (7), pp.7511-7529.
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Multi-omics surveillance of antimicrobial resistance in the pig gut microbiome

Guitart-Matas, Judith, Vera-Ponce de León, Arturo, Pope, Phillip B, Hvidsten, Torgeir R, Fraile, Lorenzo, Ballester, Maria, Ramayo-Caldas, Yuliaxis, Migura-Garcia, Lourdes (2025) Multi-omics surveillance of antimicrobial resistance in the pig gut microbiome. Animal Microbiome, 7 (1), pp.Article number: 65.
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AI-Driven Antimicrobial Peptide Discovery: Mining and Generation

Szymczak, Paulina, Zarzecki, Wojciech, Wang, Jiejing, Duan, Yiqian, Wang, Jun, Coelho, Luis Pedro, de la Fuente-Nunez, Cesar, Szczurek, Ewa (2025) AI-Driven Antimicrobial Peptide Discovery: Mining and Generation. Accounts of Chemical Research, 58 (12), pp.1831-1846.
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argNorm: normalization of antibiotic resistance gene annotations to the Antibiotic Resistance Ontology (ARO)

Ugarcina Perovic, Svetlana, Ramji, Vedanth, Chong, Hui, Duan, Yiqian, Maguire, Finlay, Coelho, Luis Pedro (2025) argNorm: normalization of antibiotic resistance gene annotations to the Antibiotic Resistance Ontology (ARO). Bioinformatics, 41 (5), pp.Article number: btaf173.
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Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity

Fountain, Adam J., Waller, Natalie J.E., Cheung, Chen Yi, Jowsey, William, Chrisp, Michael T., Troll, Mark, Edelstein, Paul H., Cook, Gregory M., McNeil, Matthew B., Ramakrishnan, Lalita (2025) Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity. Proceedings of the National Academy of Sciences of the United States of America, 122 (16), pp.Article number: e2426827122.
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Structure of Mycobacterial NDH-2 Bound to a 2-Mercapto-Quinazolinone Inhibitor

Liang, Yingke, Bueler, Stephanie A., Cook, Gregory M., Rubinstein, John L. (2025) Structure of Mycobacterial NDH-2 Bound to a 2-Mercapto-Quinazolinone Inhibitor. Journal of Medicinal Chemistry, 68 (7), pp.7579-7591.
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CompareM2 is a genomes-to-report pipeline for comparing microbial genomes

Kobel, Carl M., Aho, Velma T.E., Øyås, Ove, Nørskov-Lauritsen, Niels, Woodcroft, Ben J, Pope, Phillip B. (2025) CompareM2 is a genomes-to-report pipeline for comparing microbial genomes. Bioinformatics, 41 (9), pp.Article number: btaf517.
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Other Publications

A full list of CMR research publications can be found on the CMR Google Scholar listing.