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Thesis: Exploring the Abscopal Immune Effect of Radiotherapy and Immunotherapy Treatments in Metastatic Triple Negative Breast Cancer
Chelsea Kralik is completing her PhD with the Invasion and Metastasis Unit and the Quantitative Ultrasound Research Group of QUT. Her work explores the abscopal immune effect of stereotactic radiotherapy in combination with novel immunotherapies to combat triple negative breast cancer metastasis. Her work draws on previously performed preclinical and clinical trials to investigate (i) a range of radiotherapeutic total dose and fractionation schemes to confirm which scheme produces the most beneficial immune responses, (ii) the cellular and cytokine cascades which are cornerstone in producing a reliable and consistent abscopal effect, (iii) the representation of these effects in various non-irradiated peripheral tissues, (iv) and how these responses may be enhanced when combined with other immunotherapeutic agents.
Prior to undertaking her PhD, Chelsea completed a Bachelor of Health and Medical Sciences (Hons) with triple majors in Pathology, Neuroscience and Cellular Physiology at the University of Adelaide. Her thesis investigated the inhibition of bidirectional glycerol and water transport conducted by human Aquaporin1 and plasmodium falciparum aquaporin channels after administration of antimalarial compounds.
Chelsea’s Principal Supervisor is Dr Roberta Mazzieri with Associate Supervisors Dr Gishan Ratnayake, Professor Rik (Erik) Thompson, and A/Prof Andrew Fielding.