Accepted/in press

  1. How Stress Affects Gene Expression Through Epigenetic Modifications. Bainomugisa C and Mehta D accepted 2021.
  2. Genome-wide gene expression changes in postpartum depression points towards an altered immune landscape. Mehta D et al, 2021 Translational Psychiatry accepted.


Published papers

  1. The genetic double whammy – Autoimmune and mental health disorders. Mehta D. Brain Behav Immun. 2020 Aug 14:S0889-1591(20)31877-8.
  2. Mapping the Specific Pathways to Early-Onset Mental Health Disorders: The “Watch Me Grow for REAL” Study Protocol. Doyle FL, Mendoza Diaz A, Eapen V, Frick PJ, Kimonis ER, Hawes DJ, Moul C, Richmond JL, Mehta D, Sareen S, Morgan BG, Dadds MR. Front Psychiatry. 2020 Jun 19;11:553.
  3.  A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank. Shen X, Howard DM, Adams MJ, Hill WD, Clarke TK; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Deary IJ, Whalley HC, McIntosh AM. Nat Commun. 2020 May 8;11(1):2301.
  4. DNA methylation of NR3C1 and FKBP5 is associated with PTSD, PTG and resilience. Miller O, Shakespeare-Finch J, Bruenig D and Mehta D, Psychological Trauma: Theory, Research, Practice, and Policy, 2020.
  5. Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Coleman JRI, et al, Mol Psychiatry. 2020 Jan 23.
  6. A Systematic Review of DNA Methylation and Gene Expression Studies in Posttraumatic Stress Disorder, Posttraumatic Growth, and Resilience. Mehta D, Miller O, Bruenig D, David G, Shakespeare-Finch J. J Trauma Stress. 2020 Jan 17.
  7. Association of polygenic score for major depression with response to lithium in patients with bipolar disorder. Amare AT, et al, Mol Psychiatry. 2020 Mar 16.
  8. The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls. Coleman JRI et al, Biol Psychiatry. 2019 Nov 1.
  9. Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression. Glanville KP et al, Biol Psychiatry. 2020 Mar 1.
  10. NLRP3 is associated with coronary artery disease in Vietnam veterans. Wole Akosile W, Young R, Lawford B, Voisey J, Colquhoun D and Mehta D. Gene. 2020 Jan 30;725:144163.
  11. Molecular genetic overlap between posttraumatic stress disorder and sleep phenotypes. Lind MJ, Brick LA, Gehrman PR, Duncan LE, Gelaye B, Maihofer AX, Nievergelt CM, Nugent NR, Stein MB, Amstadter AB; Psychiatric Genomics Consortium Posttraumatic Stress Disorder. Sleep. 2019 Dec 5:zsz257.
  12. Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders. Andlauer TFM et al, Mol Psychiatry. 2019 Nov 11.
  13. International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry specific genetic risk loci. Nievergelt C et al, Nat Commun. 2019 Oct 8.
  14. GWAS of Behavioral Traits. Mehta D, Czamara D. Curr Top Behav Neurosci. 2019.
  15. Glucocorticoid-induced leucine zipper “quantifies” stressors and increases male susceptibility to PTSD. Lebow MA, Schroeder M, Tsoory M, Holzman-Karniel D, Mehta D, Ben-Dor S, Gil S, Bradley B, Smith AK, Jovanovic T, Ressler KJ, Binder EB, Chen A. Transl Psychiatry. 2019 Jul 25;9(1):178.
  16. Genome-wide gene expression in a pharmacological hormonal transition model and its relation to depressive symptoms. Mehta D, Rex-Haffner M, Søndergaard HB, Pinborg A, Binder EB, Frokjaer VG. Acta Psychiatr Scand. 2019 Jul;140(1):77-84.
  17. DNA methylation from germline cells in veterans with PTSD. Mehta D, Pelzer ES, Bruenig D, Lawford B, McLeay S, Morris CP, Gibson JN, Young RM, Voisey J; PTSD Initiative. J Psychiatr Res. 2019 Sep;116:42-50.
  18. GWAS of Suicide Attempt in Psychiatric Disorders and Association With Major Depression Polygenic Risk Scores. Mullins N, Bigdeli TB, Børglum AD, Coleman JRI, Demontis D, Mehta D et al; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium; Schizophrenia Working Group of the Psychiatric Genomics Consortium, Fanous AH, Kendler KS, McQuillin A, Lewis CM. Am J Psychiatry. 2019 Aug 1;176(8):651-660.
  19. Integrated analysis of environmental and genetic influences on cord blood DNA methylation in newborns. Czamara D, et al, Nat Commun. 2019 Jun 11;10(1):2548.
  20. Differential BDNF methylation in combat exposed veterans and the association with exercise. Voisey J, Lawford B, Bruenig D, Harvey W, Morris CP, Young RM, Mehta D; PTSD Initiative. Gene. 2019 May 25;698:107-112.
  21. Cumulative influence of parity-related genomic changes in multiple sclerosis. Mehta D, Wani S, Wallace L, Henders AK, Wray NR, McCombe PA. J Neuroimmunol. 2019 Mar 15;328:38-49.
  22. Identification of common genetic risk variants for autism spectrum disorder. Grove J, et al; Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium; BUPGEN; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; 23andMe Research Team. Nat Genet. 2019 Mar;51(3):431-444.
  23. Quantifying between-cohort and between-sex genetic heterogeneity in major depressive disorder. Trzaskowski M, Mehta D, Peyrot WJ, Hawkes D, Davies D, Howard DM, Kemper KE, Sidorenko J, Maier R, Ripke S, Mattheisen M, Baune BT, Grabe HJ, Heath AC, Jones L, Jones I, Madden PAF, McIntosh AM, Breen G, Lewis CM, Børglum AD, Sullivan PF, Martin NG, Kendler KS, Levinson DF, Wray NR; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium. Am J Med Genet B Neuropsychiatr Genet. 2019 Feb 1.
  24. Evidence for estrogen sensitivity in perinatal depression: a pharmacological sex hormone manipulation study. Mehta D, Rex-Haffner M, Søndergaard HB, Pinborg A, Binder EB and Frokjaer VG. British Journal of Psychiatry. 2019.
  25. Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. de Jong S, Diniz MJA, Saloma A, Gadelha A, Santoro ML, Ota VK, Noto C; Major Depressive Disorder and Bipolar Disorder Working Groups of the Psychiatric Genomics Consortium, Curtis C, Newhouse SJ, Patel H, Hall LS, O Reilly PF, Belangero SI, Bressan RA, Breen G. Commun Biol. 2018 Oct 8;1:163.
  26. Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank. Barbu MC, Zeng Y, Shen X, Cox SR, Clarke TK, Gibson J, Adams MJ, Johnstone M, Haley CS, Lawrie SM, Deary IJ; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; 23andMe Research Team, McIntosh AM, Whalley HC. Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Jan;4(1):91-100.
  27. The Inflammasome NLRP12 is associated with both Depression and Coronary Artery disease in Vietnam veterans. Akosile W, Young R, Lawford B, Voisey J, Colquhoun D and Mehta D. Psychiatry Research. 2018.
  28. Transcriptome analysis reveals novel genes and immune networks dysregulated in veterans with PTSD. Mehta D, Voisey J, Bruenig D, Harvey W, Morris CP, Lawford B, Young RM. Brain Behaviour Immunity. 2018 Sep 4.
  29. Analysis of shared heritability in common disorders of the brain. Brainstorm Consortium, Anttila V et al, Science. 2018 Jun 22;360(6395).
  30. An integrated -omics analysis of the epigenetic landscape of gene expression in human blood cells. Kennedy EM, Goehring GN, Nichols MH, Robins C, Mehta D, Klengel T, Eskin E, Smith AK, Conneely KN. BMC Genomics. 2018 Jun 19;19(1):476.
  31. Accelerated DNA methylation aging and increased resilience in veterans: The biological cost for soldiering on. Mehta D, Bruenig D, Lawford B, Harvey W, Carrillo-Roa T, Morris CP, Jovanovic T, Young RM, Binder EB, Voisey J. Neurobiol Stress. 2018 Apr 7;8:112-119.
  32. Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Wray NR, …86 authors (alphabetical order), Mehta D et al, Nat Genet. 2018 May;50(5):668-681.
  33. Correlation between interferon γ and interleukin 6 with PTSD and resilience. Bruenig D, Mehta D, Morris CP, Lawford B, Harvey W, McD Young R, Voisey J.Psychiatry Res. 2018 Feb;260:193-198.
  34. Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium. Peyrot WJ, et al, Biol Psychiatry. 2018 Jul 15;84(2):138-147.
  35. PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways across Biological Sex and Modes of Trauma. Breen MS, Tylee DS, Maihofer AX, Neylan TC, Mehta D, Binder EB, Chandler SD, Hess JL, Kremen WS, Risbrough VB, Woelk CH, Baker DG, Nievergelt CM, Tsuang MT, Buxbaum JD, Glatt SJ. Neuropsychopharmacology. 2018 Feb;43(3):469-481.
  36. Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes. Rietschel L, et al, Sci Rep. 2017 Nov 10;7(1):15351.
  37. Epigenetic analysis confirms no accelerated brain aging in schizophrenia. Voisey J, Lawford BR, Morris CP, Wockner LF, Noble EP, Young RM, Mehta D. NPJ Schizophr. 2017 Sep 4;3(1):26.
  38. Genome-wide DNA methylation analysis in combat veterans reveals a novel locus for PTSD. Mehta D, Bruenig D, Carrillo-Roa T, Lawford B, Harvey W, Morris CP, Smith AK, Binder EB, Young RM, Voisey J. Acta Psychiatr Scand. 2017 Aug 9.
  39. Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood. Dedic N, Pöhlmann ML, Richter JS, Mehta D, Czamara D, Metzger MW, Dine J, Bedenk BT, Hartmann J, Wagner KV, Jurik A, Almli LM, Lori A, Moosmang S, Hofmann F, Wotjak CT, Rammes G, Eder M, Chen A, Ressler KJ, Wurst W, Schmidt MV, Binder EB, Deussing JM. Mol Psychiatry. 2017 Jul 11.
  40. Nitric oxide pathway genes (NOS1AP and NOS1) are involved in PTSD severity, depression, anxiety, stress and resilience. Bruenig D, Morris CP, Mehta D, Harvey W, Lawford B, Young RM, Voisey J. Gene. 2017 Aug 20;625:42-48.
  41. Genetic effects influencing risk for major depressive disorder in China and Europe. Bigdeli TB, et al, Transl Psychiatry. 2017 Mar 28;7(3):e1074.
  42. Genetic and serum biomarker evidence for a relationship between TNFα and PTSD in Vietnam war combat veterans. Bruenig D, Mehta D, Morris CP, Harvey W, Lawford B, Young RM, Voisey J. Compr Psychiatry. 2017 Apr;74:125-133.
  43. Genome-wide Regional Heritability Mapping Identifies a Locus Within the TOX2 Gene Associated With Major Depressive Disorder. Zeng Y, et al, Biol Psychiatry. 2017 Sep 1;82(5):312-321.
  44. FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications. Gassen NC, Hartmann J, Zannas AS, Kretzschmar A, Zschocke J, Maccarrone G, Hafner K, Zellner A, Kollmannsberger LK, Wagner KV, Mehta D, Kloiber S, Turck CW, Lucae S, Chrousos GP, Holsboer F, Binder EB, Ising M, Schmidt MV, Rein T. Mol Psychiatry. 2016 Feb;21(2):277-89.
  45. Clinically proven drug targets differentially expressed in the prefrontal cortex of schizophrenia patients. Voisey J, Mehta D, McLeay R, Morris CP, Wockner LF, Noble EP, Lawford BR, Young RM. Brain Behav Immun. 2017 Mar;61:259-265.
  46. Genetic Regulation of Maternal Oxytocin Response and Its Influences on Maternal Behavior. Mehta D, Eapen V, Kohlhoff J, Mendoza Diaz A, Barnett B, Silove D, Dadds MR. Neural Plast. 2016;2016:5740365.
  47. Evidence for Genetic Overlap Between Schizophrenia and Age at First Birth in Women. Mehta D, et al, JAMA Psychiatry. 2016 May 1;73(5):497-505.
  48. Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling. Zannas AS, Arloth J, Carrillo-Roa T, Iurato S, Röh S, Ressler KJ, Nemeroff CB, Smith AK, Bradley B, Heim C, Menke A, Lange JF, Brückl T, Ising M, Wray NR, Erhardt A, Binder EB, Mehta D. Genome Biol. 2015 Dec 17;16:266.
  49. The transcriptional landscape of age in human peripheral blood. Peters MJ, et al, Nat Commun. 2015 Oct 22;6:8570.
  50. New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis. Lee SH, et al, Int J Epidemiol. 2015 Oct;44(5):1706-21.
  51. Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders. Arloth J, Bogdan R, Weber P, Frishman G, Menke A, Wagner KV, Balsevich G, Schmidt MV, Karbalai N, Czamara D, Altmann A, Trümbach D, Wurst W, Mehta D, Uhr M, Klengel T, Erhardt A, Carey CE, Conley ED; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (PGC), Ruepp A, Müller-Myhsok B, Hariri AR, Binder EB; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium PGC. Neuron. 2015 Jun 3;86(5):1189-202.
  52. Research review: Polygenic methods and their application to psychiatric traits. Wray NR, Lee SH, Mehta D, Vinkhuyzen AA, Dudbridge F, Middeldorp CM. J Child Psychol Psychiatry. 2014 Oct;55(10):1068-87.
  53. Accounting for population stratification in DNA methylation studies. Barfield RT, Almli LM, Kilaru V, Smith AK, Mercer KB, Duncan R, Klengel T, Mehta D, Binder EB, Epstein MP, Ressler KJ, Conneely KN. Genet Epidemiol. 2014 Apr;38(3):231-41.
  54. Early predictive biomarkers for postpartum depression point to a role for estrogen receptor signaling. Mehta D, Newport DJ, Frishman G, Kraus L, Rex-Haffner M, Ritchie JC, Lori A, Knight BT, Stagnaro E, Ruepp A, Stowe ZN, Binder EB. Psychol Med. 2014 Aug;44(11):2309-22.
  55. The role of DNA methylation in stress-related psychiatric disorders. Klengel T, Pape J, Binder EB, Mehta D. Neuropharmacology. 2014 May;80:115-32.18.
  56. Comprehensive survey of CNVs influencing gene expression in the human brain and its implications for pathophysiology. Mehta D, Iwamoto K, Ueda J, Bundo M, Adati N, Kojima T, Kato T. Neurosci Res. 2014 Feb;79:22-33.
  57. Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder. Mehta D, Klengel T, Conneely KN, Smith AK, Altmann A, Pace TW, Rex-Haffner M, Loeschner A, Gonik M, Mercer KB, Bradley B, Müller-Myhsok B, Ressler KJ, Binder EB. Proc Natl Acad Sci U S A (PNAS). 2013 May 14;110(20):8302-7.
  58. Transcriptional signatures related to glucose and lipid metabolism predict treatment response to the tumor necrosis factor antagonist infliximab in patients with treatment-resistant depression. Mehta D, Raison CL, Woolwine BJ, Haroon E, Binder EB, Miller AH, Felger JC. Brain Behav Immun. 2013 Jul;31:205-15.
  59. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM, Pace TW, Mercer KB, Mayberg HS, Bradley B, Nemeroff CB, Holsboer F, Heim CM, Ressler KJ, Rein T, Binder EB. Nat Neurosci. 2013 Jan;16(1):33-41.
  60. Impact of common regulatory single-nucleotide variants on gene expression profiles in whole blood. Mehta D, Heim K, Herder C, Carstensen M, Eckstein G, Schurmann C, Homuth G, Nauck M, Völker U, Roden M, Illig T, Gieger C, Meitinger T, Prokisch H. Eur J Hum Genet. 2013 Jan;21(1):48-54.
  61. Extensive natural variation for cellular hydrogen peroxide release is genetically controlled. Attar H, Bedard K, Migliavacca E, Gagnebin M, Dupré Y, Descombes P, Borel C, Deutsch S, Prokisch H, Meitinger T, Mehta D, Wichmann E, Delabar JM, Dermitzakis ET, Krause KH, Antonarakis SE. PLoS One. 2012;7(8):e43566.
  62. Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patients. Menke A, Arloth J, Pütz B, Weber P, Klengel T, Mehta D, Gonik M, Rex-Haffner M, Rubel J, Uhr M, Lucae S, Deussing JM, Müller-Myhsok B, Holsboer F, Binder EB. Neuropsychopharmacology. 2012 May;37(6):1455-64.
  63. Peripheral blood gene expression: it all boils down to the RNA collection tubes. Menke A, Rex-Haffner M, Klengel T, Binder EB, Mehta D. BMC Res Notes. 2012 Jan 4;5:1.
  64. The 5-HTTLPR polymorphism modulates the influence on environmental stressors on peripartum depression symptoms. Mehta D, Quast C, Fasching PA, Seifert A, Voigt F, Beckmann MW, Faschingbauer F, Burger P, Ekici AB, Kornhuber J, Binder EB, Goecke TW. J Affect Disord. 2012 Feb;136(3):1192-7.
  65. Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies. Mehta D, Gonik M, Klengel T, Rex-Haffner M, Menke A, Rubel J, Mercer KB, Pütz B, Bradley B, Holsboer F, Ressler KJ, Müller-Myhsok B, Binder EB. Arch Gen Psychiatry. 2011 Sep;68(9):901-10.
  66. Gene × environment vulnerability factors for PTSD: the HPA-axis. Mehta D, Binder EB. Neuropharmacology. 2012 Feb;62(2):654-62.
  67. Summaries from the XIX World Congress of Psychiatric Genetics, Washington, DC, September 10-14, 2011. Dai N, Foldager L, Gallego JA, Hack LM, Ji Y, Lett TA, Liu BC, Loken EK, Mandelli L, Mehta D, Power RA, Sprooten E, Stephens SH, Paska AV, Yan J, Zai CC, Zai G, Zhang-James Y, O’Shea A, Delisi LE. Am J Med Genet B Neuropsychiatr Genet. 2012 Jan;159B(1):128-9.
  68. Expression analysis of dopaminergic neurons in Parkinson’s disease and aging links transcriptional dysregulation of energy metabolism to cell death. Elstner M, Morris CM, Heim K, Bender A, Mehta D, Jaros E, Klopstock T, Meitinger T, Turnbull DM, Prokisch H. Acta Neuropathol. 2011 Jul;122(1):75-86.
  69. Gene expression studies in major depression. Mehta D, Menke A, Binder EB. Curr Psychiatry Rep. 2010 Apr;12(2):135-44.
  70. A common FADS2 promoter polymorphism increases promoter activity and facilitates binding of transcription factor ELK1. Lattka E, Eggers S, Moeller G, Heim K, Weber M, Mehta D, Prokisch H, Illig T, Adamski J. J Lipid Res. 2010 Jan;51(1):182-91.
  71. Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson’s disease gene. Elstner M, Morris CM, Heim K, Lichtner P, Bender A, Mehta D, Schulte C, Sharma M, Hudson G, Goldwurm S, Giovanetti A, Zeviani M, Burn DJ, McKeith IG, Perry RH, Jaros E, Krüger R, Wichmann HE, Schreiber S, Campbell H, Wilson JF, Wright AF, Dunlop M, Pistis G, Toniolo D, Chinnery PF, Gasser T, Klopstock T, Meitinger T, Prokisch H, Turnbull DM. Ann Neurol. 2009 Dec;66(6):792-8.
  72. A genome-wide association study identifies three loci associated with mean platelet volume. Meisinger C, Prokisch H, Gieger C, Soranzo N, Mehta D, Rosskopf D, Lichtner P, Klopp N, Stephens J, Watkins NA, Deloukas P, Greinacher A, Koenig W, Nauck M, Rimmbach C, Völzke H, Peters A, Illig T, Ouwehand WH, Meitinger T, Wichmann HE, Döring A. Am J Hum Genet. 2009 Jan;84(1):66-71.
  73. Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus. Weidinger S, Gieger C, Rodriguez E, Baurecht H, Mempel M, Klopp N, Gohlke H, Wagenpfeil S, Ollert M, Ring J, Behrendt H, Heinrich J, Novak N, Bieber T, Krämer U, Berdel D, von Berg A, Bauer CP, Herbarth O, Koletzko S, Prokisch H, Mehta D, Meitinger T, Depner M, von Mutius E, Liang L, Moffatt M, Cookson W, Kabesch M, Wichmann HE, Illig T. PLoS Genet. 2008 Aug;4(8):e1000166.
  74. SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. Döring A*, Gieger C*, Mehta D, et al, Nature Genetics. 2008 Apr;40(4):430-6.


Book Chapters

  1. A Zannas, Binder EB and Mehta D, 2016, “The Genomics of PTSD” chapter in book “Posttraumatic Stress Disorder: From Neurobiology to Treatment”, Editor J. Douglas Bremner, Wiley Publishers.
  2. Mehta D and Czamara D, 2018, “Statistical concepts in psychiatric genomics” invited chapter in book “Personalized Psychiatry”, Editor B. Baune, Elsevier Publishers.
  3. Czamara D and Mehta D, 2020, “Genome-wide association studies in Behavioural traits” invited chapter in book “Behavioral Neurosciences”, Editor E. Binder, Springer Publishers.
  4. Bainomugisa C and Mehta D, 2022, “How Stress Affects Gene Expression Through Epigenetic Modifications” chapter in book “Epigenetics of Stress and Stress Disorders”, Editor Y. Nagy, Elsevier Publishers.