PhD Organic Chemistry (University of Utah)
Research theme: Chemistry and Medical Biotechnology
Research discipline: Chemistry, Physics and Mechanical Engineering
- Molecular Virology
The study of molecular strategies and mechanisms employed by positive-sense single-stranded RNA viruses in the family Flaviviridae.
- Antiviral drug design
Hepatitis C-specific antiviral design, targeting novel interactions between the viral genomic RNA and trans-acting viral and host factors.
- Temporal RNA structure and function
Elucidating the role of temporal RNA secondary structure on the timing of essential viral functions.
Projects (Chief investigator)
- Functionalised RNA Aptamer Nanoparticles for Ultra-trace Detection of Target Analytes in Biological Samples via Surface Enhanced Raman Spectroscopy
- Quantitative Analysis of Commercial Dietary Supplements
- Lott B, Doran M, (2013) Do RNA viruses require genome cyclisation for replication?, Trends in Biochemical Sciences p350-355
- Marsh J, Lott B, Tyndall J, Huston W, (2013) Proteolytic activation of Chlamydia trachomatis HTRA is mediated by PDZ1 domain interactions with protease domain loops L3 and LC and beta strand beta 5, Cellular and Molecular Biology Letters p522-537
- Babur B, Ghanavi P, Levett P, Lott B, Klein T, Cooper-White J, Crawford R, Doran M, (2013) The interplay between chondrocyte redifferentiation pellet size and oxygen concentration, PLoS One p1-12
- Kabiri Renani M, Kul B, Lott W, Futrega K, Ghanavi P, Upton Z, Doran M, (2012) 3D mesenchymal stem/stromal cell osteogenesis and autocrine signalling, Biochemical and Biophysical Research Communications p142-147
- Li D, Lott W, Lowry K, Jones A, Thu H, Aaskov J, (2011) Defective interfering viral particles in acute dengue infections, PLoS One p1-12
- Romero T, Tumban E, Jun J, Lott W, Hanley K, (2006) Secondary Structure Of Dengue Virus Type 4 3 ' Untranslated Region: Impact Of Deletion And Substitution Mutations, Journal of General Virology p3291-3296
- Li D, Lott W, Martyn J, Haqshenas G, Gowans E, (2004) Differential effects on the hepatitis C virus (HCV) internal ribosome entry site by vitamin B12 and the HCV core protein, Journal of Virology p12075-12081
- Li D, Takyar S, Lott W, Gowans E, (2003) Amino acids 1-20 of the hepatitis C virus (HCV) core protein specifically inhibit HCV IRES-dependent translation in HepG2 cells, and inhibit both HCV IRES- and cap-dependent translation in HuH7 and CV-1 cells, Journal of General Virology p815-825
- Takyar S, Gowans E, Lott W, (2002) Vitamin B12 stalls the 80 S ribosomal complex on the hepatitis C internal ribosome entry site, Journal of Molecular Biology p1-8
- Lott W, Takyar S, Tuppen J, Crawford D, Harrison M, Sloots T, Gowans E, (2001) Vitamin B12 and hepatitis C: Molecular Biology and Human Pathology, Proceedings of the National Academy of Sciences p4916-4921