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PhD (University of Queensland)
Research theme: Health Research discipline: Chemistry Research program:Tissue Repair & Regeneration COVID-19 update: we are currently putting together a leading opinion article or immediate release addressing reuse of facial respirators with key recommendations. 29/3/202 Website: https://research.qut.edu.au/pnb/ Research area The inspiration behind A/Prof Dargaville's research is the development of new polymers and fabricated devices to help solve a number of important biomedical challenges. He has published 81 papers including 4 book chapters and made important contributions to the field of materials science and polymer chemistry. His areas of expertise include surface modification of polymers (PhD studies), effects of high energy radiation on polymers (post-doctoral position), synthesis of poly(2-oxazoline)s, biomaterials as implant devices, hydrogels for 3D cell culture and drug delivery devices (all part of current position at QUT). Skills include polymer synthesis (free radical and cationic mechanisms), polymer characterisation (a full suite of spectroscopic and analytical techniques), cell toxicity assays (e.g. to measure cytocompatibility of polymers with cells), and in vivo and ex vivo integration (using animal and ex vivo skin models to test biomaterial performance, integration and immune response). He is a consultant to hospitals, government laboratories and large/small companies in the areas of materials testing and new formulations. Very recently he has contributed to an Australian Diabetics Research Foundation project aimed at delivering pancreatic islets to treat type I diabetes by developing a polymer scaffold capable of enhancing blood supply to the islets and improving their viability. Areas of expertise- Polymers
- Biomaterials
- Silicone polymers
- Effects of radiation on materials including medical devices
- Poly(2-oxazoline)s as Biomaterials
- Polymer scaffolds for tissue engineering of skin and percutaneous devices
Additional information
- Huettner, N., Dargaville, T. & Forget, A. (2018). Discovering cell-adhesion peptides in tissue engineering: Beyond RGD. Trends in Biotechnology, 36(4), 372–383. https://eprints.qut.edu.au/115996
- Dargaville, T., Park, J. & Hoogenboom, R. (2018). Poly(2-oxazoline) hydrogels: State-of-the-art and emerging applications. Macromolecular Bioscience, 18(6), 1–15. https://eprints.qut.edu.au/120303
- Raveendran, R., Mullen, K., Wellard, R., Sharma, C., Hoogenboom, R. & Dargaville, T. (2017). Poly(2-oxazoline) block copolymer nanoparticles for curcumin loading and delivery to cancer cells. European Polymer Journal, 93, 682–694. https://eprints.qut.edu.au/104804
- Haigh, J., Chuang, Y., Farrugia, B., Hoogenboom, R., Dalton, P. & Dargaville, T. (2016). Hierarchically structured porous oly(2-oxazoline) hydrogels. Macromolecular Rapid Communications, 37(1), 93–99. https://eprints.qut.edu.au/89434
- Dargaville, T., Lava, K., Verbraeken, B. & Hoogenboom, R. (2016). Unexpected switching of the photogelation chemistry when cross-linking poly(2-oxazoline) copolymers. Macromolecules, 49(13), 4774–4783. https://eprints.qut.edu.au/97814
- Dalton, P., Vaquette, C., Farrugia, B., Dargaville, T., Brown, T. & Hutmacher, D. (2013). Electrospinning and additive manufacturing : converging technologies. Biomaterials Science, 1, 171–185. https://eprints.qut.edu.au/59806
- Farrugia, B., Kempe, K., Schubert, U., Hoogenboom, R. & Dargaville, T. (2013). Poly(2-oxazoline) hydrogels for controlled fibroblast attachment. Biomacromolecules, 14(8), 2724–2732. https://eprints.qut.edu.au/61888
- Dargaville, T., Farrugia, B., Broadbent, J., Pace, S., Upton, Z. & Voelcker, N. (2013). Sensors and imaging for wound healing: A review. Biosensors and Bioelectronics, 41, 30–42. https://eprints.qut.edu.au/54360
- Keddie, D., Grande, J., Gonzaga, F., Brook, M. & Dargaville, T. (2011). Amphiphilic silicone architectures via anaerobic thiol-ene chemistry. Organic Letters, 13(22), 6006–6009. https://eprints.qut.edu.au/52165
- Cipitria, A., Skelton, A., Dargaville, T., Dalton, P. & Hutmacher, D. (2011). Design, fabrication and characterization of PCL electrospun scaffolds - a review. Journal of Materials Chemistry, 21(26), 9419–9453. https://eprints.qut.edu.au/43372
- Title
- Soft Materials Containing Hierarchy via 3d Sacrificial Micro-moulding
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- FT150100408
- Start year
- 2016
- Keywords
- Title
- Convergence of Biomaterials and Immunology - A Technology Platform for Delayed Burst Release of Vaccines
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP120104611
- Start year
- 2012
- Keywords
- Vaccine Delivery; Delayed Burst Release; Electrospinning; Vaccine Implant; Immune Response
- Title
- Investigation of the Role of Transglutaminases in the Signalling of Insulin-like Growth Factor 1 and its Derivatives
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- LP110201004
- Start year
- 2011
- Keywords
- Growth Factors; Cell Signalling; Wound Healing; Cancer
- Title
- Composite Biomaterials for Modulation of Dermal Fibroblast Function
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP0877988
- Start year
- 2008
- Keywords
- Biomaterial; Hydrogel; Silicone; Fibroblast; Stratum Corneum