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Dr Miles Benton


    I am a computational geneticist interested in all facets of biology and technology, working at QUT (Queensland University of Technology) in a PostDoc Research Fellow position. In 2014 I completed my PhD exploring the underlying genetic susceptibility to obesity and metabolic disorders in the Norfolk Island population isolate. My research interests lie in the development of novel bioinformatic software for the integration and analysis of large complex data sets. I am also extremely passionate and interested in exploring ways to be able to visualise such data, providing easy to use, powerful and efficient tools back to the community. A particular focus of my recent research has been on epigenetics, including miRNA and small RNA sequencing, but more specificity investigating various methods for the processing and analysis of DNA methylation data. With the drop in cost and rapid improvement in genome sequencing, such methods are important as they allow practitioners across the applied sciences to consider greater levels of data and complexity, leading to advancement in knowledge.

    Selected publications:

    Benton MC, Sutherland HG, Macartney-Coxson D, Haupt LM, Lea RA, and Griffiths LR. (2017) Methylome-wide association study of whole blood DNA in the Norfolk Island isolate identifies robust loci associated with age. Aging [article]
    Benton MC, Lea RA, Macartney-Coxson D, Carless MA, Göring HH, Bellis C, Hanna M, Eccles D, Chambers GK, Curran JE, Harper JL, Blangero J and Griffiths LR. (2015) A phenomic scan of the Norfolk Island genetic isolate identifies a major pleiotropic effect locus associated with renal disorder markers. PLoS Genetics 11(10) [article]
    Joshi PK, … Benton MC, Lea RA, Griffiths LR, … and Wislon JF. (2015) Directional dominance on stature and cognition in diverse human populations. Nature 523(7561)
    Benton MC, Johnstone A, Eccles D, Harmon B, Hayes MT, Lea RA, Griffiths LR, Hoffman E, Stubbs RS and Macartney-Coxson D. (2015) An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight-loss. Genome Biology 16(1) [article]
    Benton MC, Lea RA, Macartney-Coxson D, Carless MA, Göring HH, Bellis C, Hanna M, Eccles D, Chambers GK, Curran JE, Harper JL, Blangero J and Griffiths LR. (2013) Mapping eQTLs in the Norfolk Island Genetic Isolate Identifies Candidate Genes for CVD-risk Traits. American Journal of Human Genetics 93(6): 1087-99 [article]