
Doctor of Philosophy - Medicine (University of Sydney)
Distinguished Professor Griffiths is an active and respected molecular geneticist with more than 30 years’ experience. DProf Griffiths has brought a translational focus to medical research to increase QUT’s influence and its impact on human health as Director of the Centre for Genomics and Personalised Health which is focused on translating knowledge from genomics research. The Centre aims to discover better methods of diagnosing disease, develop targeted treatments based on genetic information, and train the next generation of translational genomics scientists. In addition, DProf Griffiths is a passionate advocate of the translation of medical research through commercialisation and is currently the Director of the MTP Connect and industry led Bridge and BridgeTech programs, undertaking commercialisation training for the pharmaceutical and medical devices-technology fields across Australia, respectively. DProf Griffiths’ own genetics research at the Genomics Research Centre has led to diagnostic breakthroughs for several neurogenetic disorders, including familial migraine, ataxia, epilepsy and hereditary stroke. Her research has appeared in more than 400 peer-reviewed international journals and she has obtained significant competitive and industry research funds to support her research team.
Honours, Awards and prizes:
2017 HGSA, Sutherland Orator
2015 Fellow, Queensland Academy of Arts and Science
2015 Finalist, Life Sciences, Outstanding Achievement, Women in Technology
2014 Greppi Award, for the best international migraine paper Migraine Trust International Congress
2013 Gold Coast Overall Leadership Award International Women’s Day Festival 2013
2010 F1000 article factor 9 (8-9 Must read) for Nature Medicine 16(10):1157-60
2010 F1000 article factor 6 (6-7 Recommended) for Cephalalgia 31(3):264-270
2010 Research Excellence Award for Senior Researcher, Griffith University
2006 Smart State – Smart Women Finalist (Research Scientist Category);
2006 Finalist Queenslander of the Year
2005 Australian of the Year Finalist
2004 Australian Centenary Medal for Distinguished Service to Education & Medical Research
Research area: Professor Griffiths leads the Genomics Research Centre(GRC). Established in 1997, the GRC is a well equipped research centre including principal researchers, postdoctoral scientists, research assistants, postgraduate and honours students, and is funded by national competitive grants and industry collaboration and contracts. The main focus of research in the GRC is the identification of genes involved in common human disorders and the translation of this research into new diagnostics and therapeutics. Prof Griffiths has established significant genomic population resources for her research, including a unique case-controlled, multigenerational pedigree and genetic isolate from Norfolk Island. Recent studies at the GRC have mapped several migraine, CVD, MS and cancer gene loci and have implicated a number of candidate genes in disease susceptibility. The GRC undertakes regular NATA and HGSA accredited diagnostic testing for six human genetic disorders for Australasia and research to date has resulted in three fully granted and five provisional patent applications.
Research support and funding: Prof Griffiths research has been supported by more than $39M in research funding through national competitive grants, industry collaborations and contracts, and philanthropic sources including NHMRC project grants, ARC Discovery and Linkage grants, ARC EIF and NCRIS grants, Qld Smart State grants as well as international funding from the US Migraine Research Foundation.
Research interests:
- Molecular genetics
- Genetic analysis
- Chronic disease
- Clinical Trials
Additional information
- Type
- Academic Honours, Prestigious Awards or Prizes
- Reference year
- 2017
- Details
- Sutherland Orator
- Type
- Academic Honours, Prestigious Awards or Prizes
- Reference year
- 2015
- Details
- Fellow Queensland Academy of Arts and Science
- Type
- Academic Honours, Prestigious Awards or Prizes
- Reference year
- 2015
- Details
- Finalist, Life Sciences Outstanding Achievement
- Type
- Academic Honours, Prestigious Awards or Prizes
- Reference year
- 2014
- Details
- Finalist, Life Sciences Outstanding Achievement Award
- Type
- Academic Honours, Prestigious Awards or Prizes
- Reference year
- 2014
- Details
- Greppi Award: Best International Migraine Paper
- Type
- Academic Honours, Prestigious Awards or Prizes
- Reference year
- 2014
- Details
- Finalist, Life Sciences Queensland (LSQ) Industry Excellence Award
- Type
- Academic Honours, Prestigious Awards or Prizes
- Reference year
- 2013
- Details
- Gold Coast Overall Leadership Award International Women's Day Festival 2013
- Type
- Academic Honours, Prestigious Awards or Prizes
- Reference year
- 2010
- Details
- Vice Chancellor's Research Excellence Award Griffith University 2010
- Type
- Academic Honours, Prestigious Awards or Prizes
- Reference year
- 2009
- Details
- Pro Vice Chanceller (Health) Research Excellence Award Griffith University 2009
- Type
- Academic Honours, Prestigious Awards or Prizes
- Reference year
- 2005
- Details
- Queensland Finalist, Australian of the Year 2005
- Ibrahim, O., Sutherland, H., Maksemous, N., Smith, R., Haupt, L. & Griffiths, L. (2020). Exploring neuronal vulnerability to head trauma using a whole exome approach. Journal of Neurotrauma, 37(17), 1870–1879. https://eprints.qut.edu.au/205518
- Dunn, P., Maksemous, N., Sutherland, H., Haupt, L. & Griffiths, L. (2020). Investigating diagnostic sequencing techniques for CADASIL diagnosis. Human Genomics, 14. https://eprints.qut.edu.au/197429
- Pettingill, P., Weir, G., Wei, T., Wu, Y., Flower, G., Lalic, T., Handel, A., Duggal, G., Chintawar, S., Cheung, J., Arunasalam, K., Couper, E., Haupt, L., Griffiths, L., Bassett, A., Cowley, S. & Zameel Cader, M. (2019). A causal role for TRESK loss of function in migraine mechanisms. Brain, 142(12), 3852–3867. https://eprints.qut.edu.au/202677
- Sutherland, H., Albury, C. & Griffiths, L. (2019). Advances in genetics of migraine. Journal of Headache and Pain, 20. https://eprints.qut.edu.au/202431
- Schwarz, N., Bast, T., Gaily, E., Golla, G., Gorman, K., Griffiths, L., Hahn, A., Hukin, J., King, M., Korff, C., Miranda, M., Møller, R., Neubauer, B., Smith, R., Smol, T., Striano, P., Stroud, B., Vaccarezza, M., Kluger, G., Lerche, H. & Fazeli, W. (2019). Clinical and genetic spectrum of SCN2A-associated episodic ataxia. European Journal of Paediatric Neurology, 23(3), 438–447. https://eprints.qut.edu.au/202433
- Benton, M., Lea, R., MacArtney-Coxson, D., Sutherland, H., White, N., Kennedy, D., Mengersen, K., Haupt, L. & Griffiths, L. (2019). Genome-wide allele-specific methylation is enriched at gene regulatory regions in a multi-generation pedigree from the Norfolk Island isolate. Epigenetics and Chromatin, 12. https://eprints.qut.edu.au/197592
- Bradshaw, G., Haupt, L., Aquino, E., Lea, R., Sutherland, H. & Griffiths, L. (2019). Single nucleotide polymorphisms in MIR143 contribute to protection against non-Hodgkin lymphoma (NHL) in Caucasian populations. Genes, 10(3), 1–20. https://eprints.qut.edu.au/129260
- Artto, V., Färkkilä, M., Agee, M., Alipanahi, B., Auton, A., Bell, R., Bryc, K., Elson, S., Fontanillas, P., Furlotte, N., Huber, K., Kleinman, A., Litterman, N., McCreight, J., McIntyre, M., Mountain, J., Northover, C., Pitts, S., Sathirapongsasuti, J., Sazonova, O., Shelton, J., Shringarpure, S., Tian, C., Tung, J., Vacic, V., Wilson, C., Boomsma, D., Børte, S., Chasman, D., Cherkas, L., Christensen, A., Cormand, B., Cuenca-Leon, E., Davey-Smith, G., Dichgans, M., van Duijn, C., Esko, T., Esserlind, A., Ferrari, M., Frants, R., Freilinger, T., Griffiths, L., Hansen, T., Ikram, M., Ingason, A., Järvelin, M., Kajanne, R., Kallela, M., Kaprio, J., Kubisch, C., Kurth, T., Launer, L., Lessel, D., Ligthart, L., van den Maagdenberg, A., Macaya, A., Malik, R., Mangino, M., McMahon, G., Muller-Myhsok, B., Neale, B., Nyholt, D., Olesen, J., Palotie, A., Pedersen, L., Pedersen, N., Posthuma, D., Pozo-Rosich, P., Pressman, A., Quaye, L., Schürks, M., Sintas, C., Stefansson, K., Stefansson, H., Steinberg, S., Strachan, D., Terwindt, G., Vila-Pueyo, M., Wessman, M., Winsvold, B., Wrenthal, W., Zhao, H., Zwart, J., Runz, H., Daly, M., Ripatti, S., Gormley, P., Kurki, M., Hiekkala, M., Veerapen, K., Häppölä, P., Mitchell, A., Lal, D., Palta, P., Surakka, I., Kaunisto, M., Hamalainen, E., Vepsäläinen, S., Havanka, H., Harno, H., Ilmavirta, M., Nissilä, M., Säkö, E., Sumelahti, M., Liukkonen, J., Sillanpää, M., Metsähonkala, L., Koskinen, S., Lehtimäki, T., Raitakari, O., Männikkö, M., Ran, C., Belin, A., Jousilahti, P., Anttila, V. & Salomaa, V. (2018). Common variant burden contributes to the familial aggregation of migraine in 1,589 families. Neuron, 98(4), 743–753.e4. https://eprints.qut.edu.au/202429
- Bradshaw, G., Lualhati, R., Albury, C., Maksemous, N., Roos-Araujo, D., Smith, R., Benton, M., Eccles, D., Lea, R., Sutherland, H., Haupt, L. & Griffiths, L. (2018). Exome sequencing diagnoses x-linked moesin-associated immunodeficiency in a primary immunodeficiency case. Frontiers in Immunology, 9, 1–9. https://eprints.qut.edu.au/120124
- Dunn, P., Albury, C., Maksemous, N., Benton, M., Sutherland, H., Smith, R., Haupt, L. & Griffiths, L. (2018). Next generation sequencing methods for diagnosis of epilepsy syndromes. Frontiers in Genetics, 9, 1–11. https://eprints.qut.edu.au/120125
- Title
- Identifying novel gene mutations for molecular diagnosis of Familial Hemiplegic Migraine
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1122387
- Start year
- 2017
- Keywords
- Migraine; Population Genetics; Pedigree Analysis; Molecular Genetics; Sequencing
- Title
- Identifying Michondrial Genome Variants Associated with Familial Migraine Susceptibility
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1083450
- Start year
- 2015
- Keywords
- migraine; mitochondrial genetics; pedigree analysis; molecular genetics; sequencing
- Title
- Clinical Trials - Genetic Variants underlying X-linked familial migraine
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1058808
- Start year
- 2014
- Keywords
- Migraine; Molecular Genetics; Genetic Analysis; Genetic Linkage; Genetic Susceptibility
- Title
- Identifying glaucoma risk variants in the Norfolk island genetic isolate
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1058806
- Start year
- 2014
- Keywords
- Glaucoma; Risk Factors; Sequence Analysis; Phenotype-genotype Correlation; Preventive Health
- Title
- The genetic basis of human memory
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP130101921
- Start year
- 2013
- Keywords
- Human Memory; genetics; genome wide association study
- Identification of novel causative genetic and epigenetic factors in migraine
PhD, Principal Supervisor
Other supervisors: Associate Professor Larisa Haupt, Dr Heidi Sutherland - The Role of Next Generation Sequencing in Newborn Screening
PhD, Principal Supervisor
Other supervisors: Dr Hannah Carter - Investigation of Y -chromosomal markers for historical military identifications
PhD, Principal Supervisor
Other supervisors: Associate Professor Larisa Haupt - Investigating the role of common and rare and common genetic variants in migraine subtypes
PhD, Principal Supervisor
Other supervisors: Dr Heidi Sutherland