Gabrielle Bradshaw

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    PhD Candidate

    2010    Bachelor of Science (Hons), (Molecular Medicine), University of Witwatersrand

    2013     Masters Medical Research (Genomics) Griffith University

    Gabrielle Bradshaw has a B.Sc. (Hons) in Molecular Medicine and Haematology (Wits University, South Africa), a Master in Medical Research/Genomics (Griffith University, Australia), and  is currently a final year PhD Candidate. She is a qualified Medical Laboratory Scientist (Nat. Dipl. Biomedical Technology, University of Johannesburg, South Africa) with experience working full time for the National Health Laboratory Service in Johannesburg, and part-time in the Molecular Genetics pathology laboratory at the Royal Brisbane and Women’s Hospital for Queensland Health. Her research area is investigation of genetic variants in non-Hodgkin lymphoma (NHL) and primary immunodeficiency, and she has an interest in personalised medicine, diagnostic genomics, and gene therapies to treat cancer and congenital diseases.

    “I am investigating hereditary changes in DNA sequences in genes that play a role in increasing a person’s susceptibility to disorders of the immune system and B- and T-lymphocytes, such as immunodeficiency disease, where there are low lymphocytes in the blood, and also lymphoma, which is a type of cancer that causes uncontrolled proliferation of the lymphocytes in the lymph nodes. I am using a cohort of lymphoma patients and comparing their DNA sequences to a group of healthy controls who do not have cancer, to determine an association between these genetic changes and lymphoma risk. I am investigating the functional role of certain candidate genes in immunodeficiency and lymphoma by measuring their gene expression and protein levels compared to healthy controls. I am also optimising a proof-of-principle in-vitro gene editing assay to correct the causative damaging moesin mutation in a primary immunodeficiency patient using CRISPR-Cas9 technology”.

    Publications