Role in the Centre
A. Prof. Tim Dargaville is a polymer chemist with varied interests. Within QUT’s Centre for Materials Science, Tim is involved in projects spanning synthesis of polymers for drug delivery and 3-dimensional cell culture, to additive manufacturing of degradable and non-degradable materials for implants. He collaborates widely with researchers within and external to QUT on projects relating to vaccination of cattle and sheep, antibiotic nanoparticles to treat Chlamydia and surface modification of polymers to improve tissue integration of implants. Tim is also an active consultant to industry and provides materials testing expertise, epoxy formulation development and characterisation services.
A. Prof. Tim Dargaville has a BSc (Hons) from the University of Melbourne and PhD from the University of Queensland in polymer chemistry. The inspiration behind Tim’s current research is the development of new polymers and fabricated devices to help solve a number of important biomedical challenges. He has published 86 papers including 4 book chapters and made important contributions to the field of materials science and polymer chemistry. His areas of expertise include surface modification of polymers (PhD studies), effects of high energy radiation on polymers (post-doctoral position), synthesis of poly(2-oxazoline)s, biomaterials as implant devices, hydrogels for 3D cell culture and drug delivery devices (all part of current position at QUT). Skills include polymer synthesis (free radical and cationic mechanisms), polymer characterisation (a full suite of spectroscopic and analytical techniques), cell toxicity assays (e.g. to measure cytocompatibility of polymers with cells), and in vivo and ex vivo integration (using animal and ex vivo skin models to test biomaterial performance, integration and immune response). He is a consultant to hospitals, government laboratories and large/small companies in the areas of materials testing and new formulations. Recently he has contributed to an Australian Diabetics Research Foundation project aimed at delivering pancreatic islets to treat type I diabetes by developing a polymer scaffold capable of enhancing blood supply to the islets and improving their viability.
“Improving skin integration around long-term percutaneous devices using fibrous scaffolds in a reconstructed human skin equivalent model” Bolle, E.C.L; Bartnikowski, N.; Haridas, P.; Parker, T.; Fraser, J.; Gregory, S.D.; Dargaville, T. J. Biomed. Mater. Res 2020, 108(3), 738-749.
“Poly(2-oxazoline) hydrogels: State-of-the-art and emerging applications” Dargaville, T.; Park, J.R.; Hoogenboom, R. Macromol Biosci. 2018, 18(6), e1800070, 1-15.
“Discovering cell-adhesion peptides in tissue engineering: Beyond RGD” Huettner, N.; Dargaville, T.; Forget, A. Trends in Biotechnology 2018, 36(4), 372-383.
“Unexpected switching of the photogelation chemistry when cross-linking poly(2-oxazoline) copolymers” Dargaville, T.; Lava, K.; Verbraeken, B.; Hoogenboom, R. Macromolecules 2016, 49(13), 4774-4783.