Professor Steven Bottle

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Role in the Centre

Steven Bottle is an expert on free radical chemistry. His contribution to QUT’s Centre for Materials Science derives from aspects of his research related to the synthesis and application of nitroxide free radicals, an area in which he has an acknowledged international reputation. Steven’s interest in nitroxides relates to their application as antioxidant drugs and in the development of new methods for monitoring free radicals and reactive oxygen species (ROS) in cells and biological systems. He also uses this chemistry as the basis for unique technologies to monitor and assess the character of particulate pollution present in the environment. Steven has developed new additives able to provide insight into the service lifetime of polymer materials, as well as new means to rapidly degrade polymers that substantially reduce environmental waste. Steven is particularly passionate about using synthetic and free radical chemistry discovered through his research endeavours within the Centre for Materials Science to deliver new solutions to real world problems across QUT’s Research Centres, particularly in collaboration with the Centre for a Waste Free World and the Centre for Biomedical Technologies and maintains a strong focus on external industry engagement.

Short Biography

After the award of a PhD from Griffith University and following an Alexander von Humboldt Fellowship in Germany, Steven was first employed at Queensland University of Technology (QUT) in 1992 as a contract lecturer and he has subsequently risen to the rank of full Professor, holding several senior management roles over this time including Research Director at School and Faculty level. Steven started his independent research career with the goal of extending the chemistry of nitroxide free radicals to allow their applications in biology, as antioxidants and as imaging agents. Over his 30-year career to date, he has been a Chief Investigator in projects and centres totalling over $80 M sourced from the Australian Research Council, the National Health and Medical Research Council, the federal government and the private sector. This career has given him an internationally recognized reputation of expertise in the chemistry and applications of free radical chemistry, especially in the context of novel drugs and new materials, as well as how materials change upon exposure to the environment. He has more than 200 publications (>60 in the last 5 years) several patents and has received the following awards: CRC Association Excellence in Innovation Award, ARC Centre of Excellence: Outstanding Contribution Award, CRC Chairman’s Award for Excellence in Commercialisation, Vice Chancellor’s Award for Excellence, Royal Australian Chemical Institute (RACI) National Citation, Australian Academy of Science Fellowship and Alexander von Humboldt Research Fellowship. Steven is a Fellow of the RACI and was recently elected to serve as National President of the Institute for the period 2020-2022.

Selected Publications

“Pro-fluorescent mitochondria-targeted real-time responsive redox probes synthesised from carboxy isoindoline nitroxides: Sensitive probes of mitochondrial redox status in cells” Chong, K.L.; Chalmers, B.A.; Cullen, J.K.; Kaur, A.; Kolanowski, J.L.; Morrow, B.J.; Fairfull-Smith, K.E.; Lavin, M.J.; Barnett, N.L.; New, E.J.; Murphy, M.P.; Bottle, S.E. Free Radic. Biol. Med. 2018, 128, 97-110.

“Two-Photon Fluorescence Microscopy Imaging of Cellular Oxidative Stress Using Profluorescent Nitroxides” Ahn, H.-Y.; Fairfull-Smith, K.E.; Morrow, B.J.; Lussini, V.; Kim, B.; Bondar, M.V.; Bottle, S.E.; Belfield, K.D. J. Am. Chem. Soc. 2012, 134(10), 4721-4730.

“Oxidative stress is responsible for deficient survival and dendritogenesis in Purkinje neurons from ataxia-telangiectasia mutated mutant mice” Chen, P.; Peng, C.; Luff, J.; Spring, K.; Watters, D.; Bottle, S.E.; Furuya, S.; Lavin, M.F. J. Neurosci. 2003, 23(36), 11453-11460.

“Profluorescent Nitroxides as Sensitive Probes of Oxidative Change and Free Radical Reactions” Blinco, J.P.; Fairfull-Smith, K.E.; Morrow, B.J.; Bottle, S.E. Aust. J. Chem. 2011, 64(4), 373-389.

“Lifetime prediction of biodegradable polymers” Laycock, B.; Nikolic, M.; Colwell, J.M.; Gauthier, E.; Halley, P.; Bottle, S.; George, G. Prog. Polym. Sci. 2017, 71, 144-189.