Dr Hendrik Frisch

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Role in the Centre

Hendrik’s research fuses the fields of organic synthesis, peptide chemistry and polymer chemistry to generate responsive, functional materials. Within QUT’s Centre for Materials Science, Hendrik’s team develops synthetic methods that enable precise control over the molecular blueprint of polymers. Towards this goal, we merge radical polymerisations – the workhorse of industrial polymer fabrication – with nature’s building blocks of peptides. By choice of peptide sequence, we aim to program the properties of polymers for a wide range of applications. Motivated by the unrivalled reaction control enzymes display in nature, we seize combinations of polymer backbone embedded short peptide sequences and the toolbox of synthetic polymer chemistry to generate artificial enzymes. Synthetic access towards the precise chemical structure of polymers also allows tackling one of the greatest challenges of the 21st century: degradation and pollution of plastic waste. To enable controlled (bio)degradation, Hendrik develops molecular structures that incorporate inherent degradation mechanisms into polymer materials. As part of QUT’s Soft Matter Materials Laboratory, Hendrik contributes his expertise in precision photochemistry to research programs on light-gated materials within the Centre for Materials Science.

Short Biography

Hendrik received his BSc (2010) and MSc (2012) in Chemistry from the University of Münster, Germany. He completed his PhD in 2016 under the supervision of Prof. Pol Besenius at the Organic Chemistry Institutes of the Universities of Münster and Mainz. In 2017, he joined QUT’s Soft Matter Materials Laboratory as a Research Fellow of the German National Academy of Sciences working together with Prof. Barner-Kowollik. In 2019, Hendrik received a Discovery Early Career Researcher Award from the Australian Research Council funding his research program on the development of synthetic polymer-peptide hybrid materials. Until today, he has attracted over $1M in research funding from the public and private sector. Hendrik has authored more than 30 publications in leading journals and presented his research in 14 lectures on international conferences in Australia, Asia, Europe and North America.

Selected Publications

“Wavelength-Gated Photoreversible Polymerization and Topology Control” Frisch, H.; Mundsinger, K.; Poad, B.L.J.; Blanksby, S.J.; Barner-Kowollik, C. Chem. Sci. 2020, 11, 2834-2842.

“Access to Disparate Soft Matter Materials by Curing with two Colours of Light” Bialas, S.; Michalek, L.; Marschner, D.E.; Krappitz, T.; Wegener, M.; Blinco, J.P.; Blasco, E.; Frisch, H.; Barner-Kowollik, C. Adv. Matter. 2019, 31, 1807288.

“Controlling Chain Coupling and Single Chain Ligation by Two Colours of Visible Light” Frisch, H.; Bloesser, F.R.; Barner-Kowollik, C. Angew. Chem. Int. Ed. 2019, 58, 3604-3609.

“Photochemistry in Confined Environments for Single Chain Nanoparticle Design” Frisch, H.; Menzel. J.P.; Bloesser, F.R.; Marschner, D.; Mundsinger, K.; Barner-Kowollik, C. J. Am. Chem. Soc. 2018, 140, 9551−9557.

‘Kinetically Controlled Sequential Growth of Surface-Grafted Chiral Supramolecular Copolymers’ Frisch, H.; Fritz, E.-C.; Stricker, F.; Schmüser, L.; Spitzer, D.; Weidner, T.; Ravoo, B.J.; Besenius, P. Angew. Chem. Int. Ed2016, 55, 7242-7246.