Thesis Title: Application of Generative Deep Learning Models in Ophthalmic Imaging
Jason begins his PhD candidature at QUT in January 2021. His research project will investigate generative deep learning methods such as generative adversarial networks (GANs), and their application to ophthalmic images as well as the potential extensibility of new and modified techniques beyond this domain. Applications include data augmentation, super resolution, de-noising + de-artifacting, domain translation, image segmentation and anomaly detection, among others. The aim is to use these methods to improve image analysis in ophthalmology, supporting research, clinical practice and diagnostics, while the potential of applying new methods beyond this domain is likely to have general positive benefits in the area of deep learning-based image analysis.
Yoel Garcia Marin
Thesis Title: Deep learning methods applied to anterior eye optical coherence tomography images
Yoel’s research project is focused on the development of effective and automatic deep learning algorithms to be applied in anterior segment optical coherence tomography (AS-OCT) images. This covers a range of tasks including segmentation, classification and image quality assessment/improvement.
Since currently there are only a limited number of studies that have addressed the use of deep learning methods in anterior segment images, the procedures that will be developed represent a novel and innovative solution to current problems found in AS-OCT image analysis. Given the potential that deep learning methods have demonstrated in a number of imaging modalities, including the in posterior segment OCT images, this thesis aims to create effective and powerful methods that can be applied to both clinical and research applications.
Ignacio Escalona Viedma
Thesis Title: Automatic layer segmentation in retinal OCT imaging using deep learning methods
Ignacio’s research program involves the development of image analysis methods for Optical Coherence Tomography (OCT) images of the posterior segment of the eye (retina). He aims to develop accurate methods of segmentation using supervised and unsupervised Deep Learning approaches as well as pre-processing task that can support the segmentation task. The developed tools will provide automatic segmentation methods that can be used in a range of clinical and research studies. He is interested in exploring novel methods that have not been used for such an application, as well as the development of techniques that can be used in a range of different instruments (instrument-independent image analysis methods).
Thesis Title: Optical Coherence Elastography for the Measurement of Corneal and Scleral Biomechanical Properties
Zachery’s doctoral research is focused on a developing a clinical method to quantify tissue biomechanics for the anterior segment of the eye, specifically the Young’s Modulus of the cornea and sclera. This method combines static compression of the tissue under examination with Spectral Domain optical coherence tomography imaging, in a technique called optical coherence elastography. This project requires the development of both hardware and software techniques necessary to perform the experiment and to analyse the images in order to extract biomechanical properties. As there is currently limited number of methods that can assess the eye mechanical properties, the proposed method provides a novel approach of quantifying this vital parameter of the eye. Using the proposed method, may allow for early detection, and monitoring of ocular diseases including keratoconus and myopia.
Swee Chai Teoh
Thesis Title: The Eye’s Response to Vergence and Diffuse Blur
Swee Chai’s research is focused on the eye’s response to diffuse and defocus blur. Whilst animal studies have provided information about the emmetropisation process, it is not known how human eyes encode blur in modulating the growth of eyes. This study will provide insight into the understanding of the blur detection mechanism and the capability of human eyes to discern the direction of blur.
Thesis Title: Physiological corneal changes associated with scleral contact lens wear
Damien’s research will examine the physiologic effects of scleral lenses on the cornea. While scleral lenses form a small percentage of contact lens usage, they still provide great visual benefit to those that suffer corneal irregularities. Further understanding of corneal oedema and how this relates to various fitting parameters of scleral lenses will be investigated.
Various phases of his research will examine the effects of altering central fluid reservoir thickness and lens central thickness on corneal oedema during open and closed eye conditions. Another aspect of investigation involves a novel method utilising Pentacam Sheimpflug imaging to scrutinize tear dynamics within the fluid reservoir.