Peptide Therapeutics and Membrane Biology Research

Dr Sonia Henriques

Cyclic peptides are a fast-growing drug modality and hold great promise as leads to target intracellular targets, ‘undruggable’ by traditional therapies using small molecule drugs or biologics. However, their potential as therapies has not been fully achieved: active cyclic peptides are often membrane-impermeable and unable to reach targets inside cells.

Peptide Therapeutics and Membrane Biology research group led by Dr Sonia Henriques, is focused on investigating how active cyclic peptides cross cell membranes and exert their function inside cells, thereby accelerating the development of cyclic peptides in the clinic. We combine expertise in therapeutic cyclic peptides, membrane biology, molecular biophysics, and characterisation of peptide-cell membrane interactions.
The Peptide Therapeutics and Membrane Biology Research Group are located at the Translational Research Institute (TRI)