pH-dependent, antibody-mediated enhancement of genital chlamydial infection: implications for vaccine design?

Project dates: 2013-01-01 00:00:00 - 2016-06-30 00:00:00

Antibody found in cervicovaginal secretions is predominantly of the IgG subclass. In the acidic environment of the female reproductive tract IgG antibodies against surface antigens on Chlamydia may actually enhance rather than prevent infection, due to uptake of IgG-coated bacteria by the neonatal Fc receptor (FcRn), which is found on the surface of epithelial cells in the reproductive tract. The proposed studies will determine the effects of chlamydial antibodies on the course of infection.

 

Read more about the Reproductive Tract Immunology and Endometriosis Research group.


Funding / Grants

  • National Health and Medical Research Council

Dr Danica Hickey reproductive immunologist and hormone researcher