Male Chlamydia Infections: The Key Role of Macrophages in Testicular Dissemination and Disrupted Spermatogenesis

Project dates: 2018-07-01 00:00:00 - 2022-06-30 00:00:00

Chlamydia trachomatis is the most common sexually transmitted infection worldwide, with 113 million new infections per annum. Despite an equivalent incidence of infection in both sexes, research has been targeted mainly at females and the consequences of male infections are largely ignored. C. trachomatis infection causes inflammation of the urethra (urethritis), epididymis (epididymitis), prostate (prostatitis) and testes (orchitis) and has been associated with impaired spermatogenesis in many studies. The human epididymis is 5 m in length (and gt;1m in the mouse), making it highly unlikely that C trachomatis, a non-motile bacterium, reach the testis via ascending infection from the penile urethra, the site of initial infection. This is supported by our studies showing that vasectomy does not affect the testicular chlamydial burden in mice implying an alternative route of dissemination. Furthermore, within 3 days of penile infection, C Text truncated. Refer to submitted Application

Funding / Grants

  • National Health and Medical Research Council

Reproductive immunologist Alison Carey