Publications

The MinION as a cost-effective technology for diagnostic screening of the SCN1A gene in epilepsy patients

Ngo, Thi Tuyet Dieu, Lea, Rodney A., Maksemous, Neven, Eccles, David A., Smith, Robert A., Dunn, Paul J., Thao, Van Cao, Ha, Thi Minh Thi, Bùi, Chi Bao, Haupt, Larisa M., et al. (2021) The MinION as a cost-effective technology for diagnostic screening of the SCN1A gene in epilepsy patients Epilepsy Research, 172, pp.Article number: 106593.
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Barrier-to-autointegration-factor (Banf1) modulates DNA double-strand break repair pathway choice via regulation of DNA-dependent kinase (DNA-PK) activity

Burgess, Joshua, Cheong, Chee Man, Suraweera, Amila, Sobanski, Thais, Beard, Sam, Dave, Keyur, Rose, Maddison, Boucher, Didier, Croft, Laura, Adams, Mark, et al. (2021) Barrier-to-autointegration-factor (Banf1) modulates DNA double-strand break repair pathway choice via regulation of DNA-dependent kinase (DNA-PK) activity Nucleic Acids Research, pp.Article number: gkab110.

Mini review: genome and transcriptome editing using CRISPR-cas systems for haematological malignancy gene therapy

Elliott, Esther K., Haupt, Larisa M., Griffiths, Lyn R. (2021) Mini review: genome and transcriptome editing using CRISPR-cas systems for haematological malignancy gene therapy Transgenic Research.
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Long-Term Consumption of Anthocyanin-Rich Fruit Juice: Impact on Gut Microbiota and Antioxidant Markers in Lymphocytes of Healthy Males

Groh, Isabel Anna Maria, Riva, Alessandra, Braun, Dominik, Sutherland, Heidi G., Williams, Owen, Bakuradze, Tamara, Pahlke, Gudrun, Richling, Elke, Haupt, Larisa M., Griffiths, Lyn R., et al. (2021) Long‐term consumption of anthocyanin‐rich fruit juice: impact on gut microbiota and antioxidant markers in lymphocytes of healthy males Antioxidants, 10 (1), pp.Article number: 27.
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Biology of the iron efflux transporter, ferroportin

Rishi, Gautam, Subramaniam, V. Nathan (2021) Biology of the iron efflux transporter, ferroportin Advances in Protein Chemistry and Structural Biology, 123, pp.1-16.
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Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality

Adewuyi, Emmanuel O., Mehta, Divya, Sapkota, Yadav, Auta, Asa, Yoshihara, Kosuke, Nyegaard, Mette, Griffiths, Lyn R., Montgomery, Grant W., Chasman, Daniel I., Nyholt, Dale R. (2021) Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality Human Genetics, 140 (3), pp.529–552.
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Identification of proteins deregulated by platinum-based chemotherapy as novel biomarkers and therapeutic targets in non-small cell lung cancer

Ryan, Sarah-Louise, Dave, Keyur, Beard, Sam, Gyimesi, Martina, McTaggart, Matt, Sahin, Bahar, Molloy, Christopher, Gandhi, Neha, Boittier, Eric, Shah, Esha, et al. (2021) Identification of proteins deregulated by platinum-based chemotherapy as novel biomarkers and therapeutic targets in non-small cell lung cancer Frontiers in Oncology, 11, pp.Article number: 615967.

Exploring new avenues for modifying course of progression of Alzheimer's disease: The rise of natural medicine

Lye, Sarah, Aust, Caitlin E., Griffiths, Lyn R., Fernandez, Francesca (2021) Exploring new avenues for modifying course of progression of Alzheimer's disease: The rise of natural medicine Journal of the Neurological Sciences, 422, pp.Article number: 117332.
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DNA methylation of NR3C1 and FKBP5 is associated with posttraumatic stress disorder, posttraumatic growth, and resilience

Miller, Olivia, Shakespeare-Finch, Jane, Bruenig, Dagmar, Mehta, Divya (2020) DNA methylation of NR3C1 and FKBP5 is associated with posttraumatic stress disorder, posttraumatic growth, and resilience Psychological Trauma: Theory, Research, Practice, and Policy, 12 (7), pp.750-755.
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Regulatory mechanisms of epigenetic miRNA relationships in human cancer and potential as therapeutic targets

Taufiqul Arif, K. M., Elliot, Esther K., Haupt, Larisa M., Griffiths, Lyn R. (2020) Regulatory mechanisms of epigenetic miRNA relationships in human cancer and potential as therapeutic targets Cancers, 12 (10), pp.Article number: 2922.
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PARP inhibitors: Clinical relevance, mechanisms of action and tumor resistance

Rose, Maddison, Burgess, Joshua T., O’Byrne, Kenneth, Richard, Derek J., Bolderson, Emma (2020) PARP inhibitors: Clinical relevance, mechanisms of action and tumor resistance Frontiers in Cell and Developmental Biology, 8, pp.Article number: 564601.
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HSPGs glypican‐1 and glypican‐4 are human neuronal proteins characteristic of different neural phenotypes

Oikari, Lotta E., Yu, Chieh, Okolicsanyi, Rachel K., Avgan, Nesli, Peall, Ian W., Griffiths, Lyn R., Haupt, Larisa M. (2020) HSPGs glypican‐1 and glypican‐4 are human neuronal proteins characteristic of different neural phenotypes Journal of Neuroscience Research, 98 (8), pp.1619-1645.
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Exploring neuronal vulnerability to head trauma using a whole exome approach

Ibrahim, Omar, Sutherland, Heidi G., Maksemous, Neven, Smith, Robert, Haupt, Larisa M., Griffiths, Lyn R. (2020) Exploring neuronal vulnerability to head trauma using a whole exome approach Journal of Neurotrauma, 37 (17), pp.1870-1879.
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High-plex and high-throughput digital spatial profiling of non-small-cell lung cancer (NSCLC)

Monkman, James, Taheri, Touraj, Warkiani, Majid Ebrahimi, O’leary, Connor, Ladwa, Rahul, Richard, Derek, O’ Byrne, Ken, Kulasinghe, Arutha (2020) High-plex and high-throughput digital spatial profiling of non-small-cell lung cancer (NSCLC) Cancers, 12 (12), pp.Article number: 3551.
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Unilateral autoimmune inner ear disease in a patient with lung cancer treated with nivolumab

Rajapakse, Aleksandra, O'Leary, Connor Gerard, Gundelach, Raefe, Deva, Rajeev, O'Byrne, Ken (2020) Unilateral autoimmune inner ear disease in a patient with lung cancer treated with nivolumab Oxford Medical Case Reports, 2020 (9), pp.Article number: omaa077 326-329.
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The genetic double whammy: Autoimmune and mental health disorders

Mehta, Divya (2020) The genetic double whammy: Autoimmune and mental health disorders Brain, Behavior, and Immunity, 89, pp.7-8.
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Redox regulation in the base excision repair pathway: Old and new players as cancer therapeutic targets

Rajapakse, Aleksandra, Suraweera, Amila, Boucher, Didier, Jaffary, Syed Ali Naqi Raza, O'Byrne, Ken, Richard, Derek, Croft, Laura (2020) Redox regulation in the base excision repair pathway: Old and new players as cancer therapeutic targets Current Medicinal Chemistry, 27 (12), pp.1901-1921.
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Epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC)

O’Leary, Connor, Gasper, Harry, Sahin, Katherine B., Tang, Ming, Kulasinghe, Arutha, Adams, Mark N., Richard, Derek J., O’Byrne, Ken J. (2020) Epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC) Pharmaceuticals, 13 (10), pp.Article number: 273.
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Circulating tumor cells in metastatic breast cancer: From genome instability to metastasis

Ivanova, Ekaterina, Ward, Ambber, Wiegmans, Adrian P., Richard, Derek John (2020) Circulating tumor cells in metastatic breast cancer: From genome instability to metastasis Frontiers in Molecular Biosciences, 7, pp.Article number: 134.
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Hepatocyte-specific deletion of peroxisomal protein PEX13 results in disrupted iron homeostasis

Rishi, Gautam, Bhatia, Maneet, Secondes, Eriza S., Melino, Michelle, Crane, Denis I., Subramaniam, V. Nathan (2020) Hepatocyte-specific deletion of peroxisomal protein PEX13 results in disrupted iron homeostasis Biochimica et Biophysica Acta - Molecular Basis of Disease, 1866 (10), pp.Article number: 165882.
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Dysregulated hepcidin response to dietary iron in male mice with reduced Gnpat expression

Rishi, Gautam, Secondes, Eriza S, Asplett, Kiran, Wallace, Daniel F, Ostini, Lesa, Berger, Johannes, Subramaniam, V Nathan (2020) Dysregulated hepcidin response to dietary iron in male mice with reduced Gnpat expression Bioscience Reports, 40 (8), pp.Article number: BSR20201508.
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Investigating the influence of mtDNA and nuclear encoded mitochondrial variants on high intensity interval training outcomes

Harvey, N. R., Voisin, S., Lea, R. A., Yan, X., Benton, M. C., Papadimitriou, I. D., Jacques, M., Haupt, L. M., Ashton, K. J., Eynon, N., et al. (2020) Investigating the influence of mtDNA and nuclear encoded mitochondrial variants on high intensity interval training outcomes Scientific Reports, 10 (1), pp.Article number: 11089.
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The Therapeutic Potential of DNA Damage Repair Pathways and Genomic Stability in Lung Cancer

Burgess, Joshua T., Rose, Maddison, Boucher, Didier, Plowman, Jennifer, Molloy, Christopher, Fisher, Mark, O'Leary, Connor, Richard, Derek J., O'Byrne, Kenneth J., Bolderson, Emma (2020) The Therapeutic Potential of DNA Damage Repair Pathways and Genomic Stability in Lung Cancer Frontiers in Oncology, 10, pp.Article number: 1256.
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Increased frequency of GNPAT p.D519G in compound HFE p.C282Y/p.H63D heterozygotes with elevated serum ferritin levels

Secondes, Eriza S., Wallace, Daniel F., Rishi, Gautam, McLaren, Gordon D., McLaren, Christine E., Chen, Wen Pin, Ramm, Louise E., Powell, Lawrie W., Ramm, Grant A., Barton, James C., et al. (2020) Increased frequency of GNPAT p.D519G in compound HFE p.C282Y/p.H63D heterozygotes with elevated serum ferritin levels Blood Cells, Molecules, and Diseases, 85, pp.Article number: 102463.
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Assessing molecular docking tools to guide targeted drug discovery of CD38 inhibitors

Boittier, Eric, Tang, Yat Yin, Buckley, McKenna, Schuurs, Zachariah, Richard, Derek, Gandhi, Neha S. (2020) Assessing molecular docking tools to guide targeted drug discovery of CD38 inhibitors International Journal of Molecular Sciences, 21 (15), pp.Article number: 5183.
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The evolving landscape of predictive biomarkers in immuno‐oncology with a focus on spatial technologies

Sadeghi Rad, Habib, Bazaz, Sajad Razavi, Monkman, James, Ebrahimi Warkiani, Majid, Rezaei, Nima, O'Byrne, Ken, Kulasinghe, Arutha (2020) The evolving landscape of predictive biomarkers in immuno‐oncology with a focus on spatial technologies Clinical and Translational Immunology, 9 (11), pp.Article number: e1215.
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Comprehensive Exonic Sequencing of Hemiplegic Migraine-Related Genes in a Cohort of Suspected Probands Identifies Known and Potential Pathogenic Variants

Sutherland, Heidi G., Maksemous, Neven, Albury, Cassie L., Ibrahim, Omar, Smith, Robert A., Lea, Rod A., Haupt, Larisa M., Jenkins, Bronwyn, Tsang, Benjamin, Griffiths, Lyn R. (2020) Comprehensive Exonic Sequencing of Hemiplegic Migraine-Related Genes in a Cohort of Suspected Probands Identifies Known and Potential Pathogenic Variants Cells, 9 (11), pp.Article number: 2638.
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Circulating tumor cell clusters: Insights into tumour dissemination and metastasis

Herath, Sayuri, Razavi Bazaz, Sajad, Monkman, James, Ebrahimi Warkiani, Majid, Richard, Derek, O’Byrne, Ken, Kulasinghe, Arutha (2020) Circulating tumor cell clusters: Insights into tumour dissemination and metastasis Expert Review of Molecular Diagnostics, 20 (11), pp.1139-1147.
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A comparative study of multi-omics integration tools for cancer driver gene identification and tumour subtyping

Sathyanarayanan, Anita, Gupta, Rohit, Thompson, Rik, Nyholt, Dale, Bauer, Denis, Hiriyur Nagaraj, Shivashankar (2020) A comparative study of multi-omics integration tools for cancer driver gene identification and tumour subtyping Briefings in Bioinformatics, 21 (6), pp.1920-1936.
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