Functional genomics aims to advance our understanding of molecular mechanisms and defining the relationship between an organism’s genome and its phenotype by studying the function and interactions of genes. Functional genomics seeks to uncover the roles that genes play in various biological processes, as well as how they contribute to the overall functioning of cells and organisms. The application of Gene function analysis, Gene expression profiling, Functional screens, Proteomics, Metabolomics, Spatial transcriptomics/proteomics are used to understand gene functions and interactions to establish genome/phenotype interactions indicative of disease processes. These biomarkers can then be used to develop novel diagnostic and treatment strategies.
Functional Genomics Domain Leader - Associate Professor Larisa Haupt
Associate Professor Larisa Haupt is the Stem Cell and Neurogenesis Group Leader and Diagnostics and Functional Genomics Program Co-Leader within the Centre for Genomics and Personalised Health at QUT. A/Prof Haupt has extensive research expertise in the extracellular matrix, stem cells, cell and molecular biology and human molecular genetics. Her research team has a particular interest in the role of the extracellular matrix, with a focus on the proteoglycans, in the regulation and dysregulation of cell behaviour including lineage specification and cancer. A/Prof Haupt and her team utilise molecular and cell biological in two- and three-dimensional culture models as well as next generation sequencing platforms to unravel these complex mechanisms in humans. She and her team have identified a role for HSPGs in human neural stem cells (hNSC) proliferation and lineage specification and a potential role for these important proteins in breast cancer tumorgenicity.
View Associate Professor Larisa Haupt’s profile