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PhD (Bioengineering) (University of California)
Professor Travis Klein is the Director of the Centre for Biomedical Technologies and the leader of the Cartilage Regeneration Laboratory (CRL) at Queensland University of Technology (QUT). The Centre for Biomedical Technologies aims to deliver better health in our lifetime, by improving how we treat complex medical cases stemming from injuries, infection and age-related issues. Our research and development focuses on better patient treatments and quality of life into the future using regenerative approaches, robotics and artificial intelligence, and advanced manufacturing to expand surgical possibilities and reduce complications. The ultimate aim of the CRL is to help develop long-term regenerative therapies for treating cartilage defects, including osteoarthritis. One particular area of interest has been in understanding the differences between chondrocytes and extracellular matrix of different depth zones, and recapitulating these in vitro. To help understand chondrogenesis and joint pathologies, and engineer functional tissues, Travis' group is developing:
- functional biomaterials
- 3D cell culture systems
- biofabrication approaches
- mechanical stimulation technologies
In addition to cartilage tissue engineering, the CRL applies similar approaches and technologies towards cardiovascular and cancer applications.
Google Scholar link: http://scholar.google.com.au/citations?user=RYS5blIAAAAJ
Additional information
Travis is co-founder of Gelomics Pty Ltd., which enables researchers through high quality and easy to use materials and devices for 3D cell culture.
- Type
- Recipient of a Nationally Competitive Research Fellowship
- Reference year
- 2011
- Details
- Fellowship Type: ARC Principal Research FellowshipProject Title: Regenerating articular cartilage with smart hydrogels and fabrication technologiesExternal Reference : FT110100166Years Awarded: 2011 - 2015Total Funding Awarded: $639,288
- Type
- Recipient of a Nationally Competitive Research Fellowship
- Reference year
- 2008
- Details
- DP0878365- APD (2008-2010)Australian Postdoctoral Fellowship (APD) "Engineering Articular Cartilage with Zonal Structure and Function"
- Weekes, A., Bartnikowski, N., Pinto, N., Jenkins, J., Meinert, C. & Klein, T. (2022). Biofabrication of small diameter tissue-engineered vascular grafts. Acta Biomaterialia, 138, 92–111. https://eprints.qut.edu.au/231330
- Gormley, A., Horgan, C., Black, C., Meinert, C., Klein, T., Saifzadeh, S., Steck, R., Ren, J., Woodruff, M., Stevens, M., Steele, J., Moore, A., St-Pierre, J. & McCullen, S. (2022). In vitro and in vivo investigation of a zonal microstructured scaffold for osteochondral defect repair. Biomaterials, 286. https://eprints.qut.edu.au/231989
- Forrestal, D., Allenby, M., Simpson, B., Klein, T. & Woodruff, M. (2022). Personalized Volumetric Tissue Generation by Enhancing Multiscale Mass Transport through 3D Printed Scaffolds in Perfused Bioreactors. Advanced Healthcare Materials, 11(24). https://eprints.qut.edu.au/233923
- Futrega, K., Robey, P., Klein, T., Crawford, R. & Doran, M. (2021). A single day of TGF-ß1 exposure activates chondrogenic and hypertrophic differentiation pathways in bone marrow-derived stromal cells. Communications Biology, 4. https://eprints.qut.edu.au/209587
- Lawson, T., Mäkelä, J., Klein, T., Snyder, B. & Grinstaff, M. (2021). Nanotechnology and Osteoarthritis. Part 2: Opportunities for advanced devices and therapeutics. Journal of Orthopaedic Research, 39(3), 473–484. https://eprints.qut.edu.au/206474
- Pahoff, S., Meinert, C., Bas, O., Nguyen, B., Klein, T. & Hutmacher, D. (2019). Effect of gelatin source and photoinitiator type on chondrocyte redifferentiation in gelatin methacryloyl-based tissue-engineered cartilage constructs. Journal of Materials Chemistry B, 7(10), 1761–1772. https://eprints.qut.edu.au/128675
- Meinert, C., Schrobback, K., Hutmacher, D. & Klein, T. (2017). A novel bioreactor system for biaxial mechanical loading enhances the properties of tissue-engineered human cartilage. Scientific Reports, 7, 1–14. https://eprints.qut.edu.au/115053
- Bas, O., Juan Pardo, E., Meinert, C., Baldwin, J., Bray, L., Wellard, R., Klein, T. & Hutmacher, D. (2017). Biofabricated soft network composites for cartilage tissue engineering. Biofabrication, 9(2), 1–15. https://eprints.qut.edu.au/107693
- Loessner, D., Meinert, C., Kammerer, E., Martine, L., Yue, K., Levett, P., Klein, T., Melchels, F., Khademhosseini, A. & Hutmacher, D. (2016). Functionalization, preparation and use of cell-laden gelatin methacryloyl-based hydrogels as modular tissue culture platforms. Nature Protocols, 11(4), 727–746. https://eprints.qut.edu.au/102207
- Levett, P., Melchels, F., Schrobback, K., Hutmacher, D., Malda, J. & Klein, T. (2014). A biomimetic extracellular matrix for cartilage tissue engineering centered on photocurable gelatin, hyaluronic acid and chondroitin sulfate. Acta Biomaterialia, 10(1), 214–223. https://eprints.qut.edu.au/64930
- Title
- ARC Industrial Transformation Training Centre for Joint Biomechanics
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- IC190100020
- Start year
- 2020
- Keywords
- Title
- ARC ITTC (CTET) for Cell and Tissue Engineering Technologies
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- IC190100026
- Start year
- 2019
- Keywords
- Title
- A Novel Multiscale Model to Investigate Mechanical Properties of Cartilage
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP180103009
- Start year
- 2018
- Keywords
- Title
- ARC Training Centre in Additive Biomanufacturing
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- IC160100026
- Start year
- 2017
- Keywords
- Title
- Coupling an injectable gel and MSC microtissues to enhance cartilage repair
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1083857
- Start year
- 2015
- Keywords
- cartilage; regenerative medicine; stem cell therapy; biomedical engineering; biomaterials
- Title
- Bioactivated hierarchical hydrogels as zonal implants for articular cartilage regeneration
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1067108
- Start year
- 2014
- Keywords
- Cartilage Damage; Cell Differentiation; Chondrocytes; Osteoarthritis; Stem Cells
- Title
- MAPK/ERK pathway in osteoarthritis
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- 1032738
- Start year
- 2012
- Keywords
- osteoarthritis; pathogenesis; cell signalling; kinases; animal model
- Title
- Regenerating articular cartilage with smart hydrogels and fabrication technologies
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- FT110100166
- Start year
- 2012
- Keywords
- Cartilage; Regenerative Medicine; Biofabrication
- Title
- Interplay Between Mechanical and Biological Microenvironments in Chondrocyte Function: Towards an Understanding of Cartilage Pathology
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP110103543
- Start year
- 2011
- Keywords
- Cartilage; Arthritis; Biomaterials; Lubrication; Hydrogel
- Title
- Engineering Articular Cartilage with Zonal Structure and Function
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- DP0878365
- Start year
- 2008
- Keywords
- Arthritis; Cartilage; Tissue Engineering; Regenerative Medicine; Scaffold; Stem Cells
- Photocrosslinkable Hydrogels for Cartilage Tissue Engineering (2016)
- Design and Characterisation of Scaffolds for Osteochondral Regeneration (2015)
- Environments for Zonal Cartilage Tissue Engineering (2015)
- Development of Zonal Cartilage Constructs: Effects of Chondrocyte Subpopulation, Compressive Stimulation, and Culture Models (2012)
- In Vitro Cultivation of Adult Human Chondrocytes: Importance of Culture System, Oxygen and Zonal Differences (2010)