PhD (Queensland University of Technology), Bachelor of Applied Science (Honours) (Queensland University of Technology)
Dr Jacqui McGovern is an interdisciplinary researcher who utilizes biomaterials and tissue engineering techniques to generate in vitro and in vivo models of bone metastatic cancers (e.g. breast and prostate cancer), as well as bone-resident tumours (osteosarcoma and multiple myeloma). She has expertise in 3D tissue models of complex organs, such as skin and bone. Her research aims to use these advanced models to study fundamental interactions between cancer cells and the human bone microenvironment, with the ultimate goal of improving the quality of life for patients affected by metastatic cancer. Dr McGovern has received support from the International Myeloma Foundation, Cancer Australia and Advance Queensland.
Additional information
- Lahr, C., Landgraf, M., Sanchez Herrero, A., Dang, H., Wagner, F., Bas, O., Bray, L., Tran, P., Holzapfel, B., Shafiee, A., Mcgovern, J. & Hutmacher, D. (2020). A 3D-printed biomaterials-based platform to advance established therapy avenues against primary bone cancers. Acta Biomaterialia, 118, 69–82. https://eprints.qut.edu.au/205729
- McGovern, J., Steck, R., Wagels, M., Woodruff, M., Schuetz, M., Hutmacher, D., Sparks, D., Saifzadeh, S., Savi, F., Dlaska, C., Berner, A., Henkel, J., Reichert, J., Wullschleger, M., Ren, J. & Cipitria, A. (2020). A preclinical large-animal model for the assessment of critical-size load-bearing bone defect reconstruction. Nature Protocols, 15(3), 877–924. https://eprints.qut.edu.au/202269
- Sanchez-Herrero, A., Calvo, I., Flandes-Iparraguirre, M., Landgraf, M., Lahr, C., Shafiee, A., Granero-Molto, F., Saez, B., Mazo, M., Paiva, B., Pardo, E., Nicol, A., Prosper, F., Bray, L. & McGovern, J. (2020). Engineering a humanised niche to support human haematopoiesis in mice: Novel opportunities in modelling cancer. Cancers, 12(8). https://eprints.qut.edu.au/203819
- Landgraf, M., Lahr, C., Kaur, I., Shafiee, A., Sanchez-Herrero, A., Janowicz, P., Ravichandran, A., Howard, C., Cifuentes-Rius, A., McGovern, J., Voelcker, N. & Hutmacher, D. (2020). Targeted camptothecin delivery via silicon nanoparticles reduces breast cancer metastasis. Biomaterials, 240. https://eprints.qut.edu.au/203820
- Wagner, F., Holzapfel, B., Martine, L., Mcgovern, J., Lahr, C., Boxberg, M., Prodinger, P., Grassel, S., Loessner, D. & Hutmacher, D. (2019). A humanized bone microenvironment uncovers HIF2 alpha as a latent marker for osteosarcoma. Acta Biomaterialia, 89, 372–381. https://eprints.qut.edu.au/127266
- Landgraf, M., Lahr, C., Sanchez-Herrero, A., Meinert, C., Shokoohmand, A., Pollock, P., Hutmacher, D., Shafiee, A. & McGovern, J. (2019). Humanized bone facilitates prostate cancer metastasis and recapitulates therapeutic effects of zoledronic acid in vivo. Bone Research, 7. https://eprints.qut.edu.au/203778
- Mcgovern, J., Griffin, M. & Hutmacher, D. (2018). Animal models for bone tissue engineering and modelling disease. DMM Disease Models and Mechanisms, 11(4), 1–14.
- Wagner, F., Holzapfel, B., McGovern, J., Shafiee, A., Baldwin, J., Martine, L., Lahr, C., Wunner, F., Friis, T., Bas, O., Boxberg, M., Prodinger, P., Shokoohmand, A., Moi, D., Mazzieri, R., Loessner, D. & Hutmacher, D. (2018). Humanization of bone and bone marrow in an orthotopic site reveals new potential therapeutic targets in osteosarcoma. Biomaterials, 171, 230–246. https://eprints.qut.edu.au/223852
- McGovern, J., Shafiee, A., Wagner, F., Lahr, C., Landgraf, M., Meinert, C., Williams, E., Russell, P., Clements, J., Loessner, D., Holzapfel, B., Risbridger, G. & Hutmacher, D. (2018). Humanization of the prostate microenvironment reduces homing of PC3 prostate cancer cells to human tissue-engineered bone. Cancers, 10(11), 1–15. https://eprints.qut.edu.au/123040
- Shafiee, A., McGovern, J., Lahr, C., Meinert, C., Moi, D., Wagner, F., Landgraf, M., Juan Pardo, E., Mazzieri, R. & Hutmacher, D. (2018). Immune system augmentation via humanization using stem/progenitor cells and bioengineering in a breast cancer model study. International Journal of Cancer, 143(6), 1470–1482. https://eprints.qut.edu.au/223790
- Title
- Humanized Rat Models - The Next Frontier in Preclinical Osteosarcoma Research
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- CA-APP1181919
- Start year
- 2021
- Keywords
- Osteosarcoma; Tissue Engineering; Bone Defects; Regenerative Medicine; Surgical Procedures
- Title
- ARC ITTC (CTET) for Cell and Tissue Engineering Technologies
- Primary fund type
- CAT 1 - Australian Competitive Grant
- Project ID
- IC190100026
- Start year
- 2019
- Keywords
- The role of bone marrow fat in advanced prostate cancer using bioengineered humanized models
PhD, Associate Supervisor
Other supervisors: Dr Nathalie Bock, Distinguished Professor Dietmar W Hutmacher, Dr Jennifer Gunter - Tissue engineering a humanized rat model for osteosarcoma research
PhD, Principal Supervisor
Other supervisors: Distinguished Professor Dietmar W Hutmacher - Scaffold-Guided Breast Tissue Engineering: Use of large volume 3D printed multiphasicimplants for controlled antibiotic delivery
PhD, Associate Supervisor
Other supervisors: Distinguished Professor Dietmar W Hutmacher - BONE LOSS: APPLICATION OF TRANSLATIONAL REGENERATIVE MEDICINE TOWARDS IMPROVED TREATMENT STRATEGIES
PhD, Associate Supervisor
Other supervisors: Distinguished Professor Dietmar W Hutmacher, Dr Nathalie Bock
- Tissue-Engineering Humanised Bone Sarcoma Models in Rodents - A Preclinical Study Platform For Orthopaedic Research (2021)
- A Humanized Model to Investigate Targeted Therapeutic Strategies Against Cancer Bone Metastasis (2020)
- Convergence of Bioengineering, Orthopaedics and Tumour Biology to Develop and Validate Humanized Rodent Models for Primary Bone Tumour Research (2018)
- In Vitro Characterisation of Melanoma Progression in a Melanoma Skin Equivalent Model (2018)