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PhD (University of Keele, Staffordshire (UK))
Kevin Dudley undertook his PhD in the area of epigenetics and pituitary tumour development. Since then he has continued to work in the epigenetics field utilising model systems to explore phenomena such as the developmental origins of disease and cellular mechanisms of learning and memory. He joined QUT's Central Analytical Research Facility in 2013. In this role his responsibilities include providing genomics-related research support, teaching and training, as well as continuing to pursue independent research. His current research is focussed on a variety of "non-model" species that have particular relevance to Australia. Integral to this research are sophisticated technologies such as next generation sequencing, proteomics and genome editing. As well as providing novel insights into the role that epigenetic mechanisms play in fundamental processes such as development and evolution, this research aims to make an active contribution to enhancing the global bioeconomy.
Projects
Additional information
- Philips, J., Dudley, K., Waterhouse, P. & Hellens, R. (2019). The rapid methylation of T-DNAs upon agrobacterium inoculation in plant leaves. Frontiers in Plant Science, 10, 1–17. https://eprints.qut.edu.au/127853
- Nagalingam, K., Lorenc, M., Manoli, S., Cameron, S., Clarke, A. & Dudley, K. (2018). Chromatin immunoprecipitation (ChIP) method for non-model fruit flies (Diptera: Tephritidae) and evidence of histone modifications. PLoS One, 13(3), 1–13. https://eprints.qut.edu.au/223793
- Rotllant, G., Nguyen, T., Sbragaglia, V., Rahi, M., Dudley, K., Hurwood, D., Ventura, T., Company, J., Chand, V., Aguzzi, J. & Mather, P. (2017). Sex and tissue specific gene expression patterns identified following de novo transcriptomic analysis of the Norway lobster, Nephrops norvegicus. BMC Genomics, 18, 1–14. https://eprints.qut.edu.au/110293
- Philips, J., Eftekhari, F., Lorenc, M., Dudley, K., Hellens, R. & Waterhouse, P. (2017). The widely used Nicotiana benthamiana 16c line has an unusual T-DNA integration pattern including a transposon sequence. PLoS One, 12(2), 1–9. https://eprints.qut.edu.au/103951
- Dudley, K., Li, X., Kobor, M., Kippin, T. & Bredy, T. (2011). Epigenetic mechanisms mediating vulnerability and resilience to psychiatric disorders. Neuroscience and Biobehavioral Reviews, 35(7), 1544–1551. https://eprints.qut.edu.au/75092
- Dudley, K., Sloboda, D., Connor, K., Beltrand, J. & Vickers, M. (2011). Offspring of mothers fed a high fat diet display hepatic cell cycle inhibition and associated changes in gene expression and DNA methylation. PLoS One, 6(7), 1–8. https://eprints.qut.edu.au/75091
- Marek, R., Coelho, C., Sullivan, R., Baker-Andresen, D., Li, X., Ratnu, V., Dudley, K., Meyers, D., Mukherjee, C., Cole, P., Sah, P. & Bredy, T. (2011). Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300. Journal of Neuroscience, 31(20), 7486–7491. https://eprints.qut.edu.au/75093
- Lin, Q., Wei, W., Coelho, C., Li, X., Baker-Andresen, D., Dudley, K., Ratnu, V., Boskovic, Z., Kobor, M., Sun, Y. & Bredy, T. (2011). The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory. Nature Neuroscience, 14(9), 1115–1117. https://eprints.qut.edu.au/75090
- Revill, K., Dudley, K., Clayton, R., McNicol, A. & Farrell, W. (2009). Loss of neuronatin expression is associated with promoter hypermethylation in pituitary adenoma. Endocrine-Related Cancer, 16(2), 537–548. https://eprints.qut.edu.au/75094
- Dudley, K., Revill, K., Whitby, P., Clayton, R. & Farrell, W. (2008). Genome-wide analysis in a murine Dnmt1 knockdown model identifies epigenetically silenced genes in primary human pituitary tumors. Molecular Cancer Research, 6(10), 1567–1574. https://eprints.qut.edu.au/75096
- Bioprospecting, and characterization of plastic and plasticizer degrading enzymes from Great Australian Artesian Basin thermophiles for biorecycling and bioremediation
PhD, Associate Supervisor
Other supervisors: Adjunct Associate Professor Junior Te'o, Dr Pawel Sadowski