Dr Carlos Horacio Luna-Flores

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Bachelor: Biotechnology Engineering.

Master: Master in Sciences in Biotechnological Processes.

Diploma: Diploma in Pharmaceutical Biotechnology.

PhD: PhD in Chemical and Biological Sciences.

Carlos H. Luna-Flores completed his bachelor degree in Biotechnology Engineer from the Technological Institute of Sonora in July 2000. After, he obtained his Master in Science degree in Biotechnological Processes from The University of Guadalajara in May 2006. Once concluded his master degree, Carlos worked as a Biochemist and Researcher of Bioreactors inside the Research and Development department of Cryopharma Laboratories; the activities of Carlos on this position included the development and optimization of fermentative bioprocesses to produce proteins with industrial interest using recombinant mammalian cells and instrumented fermenters. After, Carlos worked as a Biochemist and Biotechnology Engineering inside the Process Improvement Department of the company Boehringer Ingelheim – animal health. Here, Carlos worked with the optimization and scale up of fermentative bioprocesses to produce active compounds of vaccines – proteins or biomass – using bacteria and the Bacoulovirus Insect Cell Expression System. After six years of industry working experience, Carlos decided to continue with his PhD studies, and in March 2017, Carlos received his PhD Higher Research Degree in Chemical and Biological Sciences from the Australian Institute for Bioengineering and Nanotechnology – The University of Queensland (UQ). Here Carlos worked with the understanding of propionic acid production in anaerobic bacteria using systems biology tools such as Genome Scuffling, Genomics, Proteomics, Transcriptomics, and Metabolomics. Following the award of his PhD, Carlos commenced work with Bioproton as a Research and Development Scientist inside an Advance Queensland Knowledge Transfer Partnership – Bioproton and Queensland University of Technology (QUT). Here Carlos worked with the development of high-yield astaxanthin strains of Phaffia rhodozyma. The success and progress on the project motivated to apply to other grants, and in November 2018, Carlos was awarded for the prestigious and highly competitive Advance Queensland Industry Fellowship – Bioproton Pty Ltd and QUT. Under this project, Carlos has been working with advanced systems biology tools to improve production of astaxanthin in previously obtained high-yield strains of Phaffia rhodozyma. In addition, Carlos is collaborating in a QUT and Bioproton Pty Ltd project to optimize and scale-up fermentative processes of enzymes production using the Pichia pastoris expression system.

Publications

H. Luna-Flores, L. K. Nielsen, E. Marcellin, C. Stowers, B. F. Martins, and B. M. Cox, “IMPROVED PROPIONIBACTERIUM STRAINS FOR THE PRODUCTION OF PROPIONIC ACID,” Patent: US 2019 / 0071697 A1, 2019.

H. Luna-Flores, C. C. Stowers, B. M. Cox, L. K. Nielsen, and E. Marcellin, “Linking genotype and phenotype in an economically viable propionic acid biosynthesis process,” Biotechnol. Biofuels, vol. 11, no. 1, p. 224, Dec. 2018.

H. Luna-Flores ,Lars K Nielsen, “Genome sequence of Propionibacterium acidipropionici ATCC 55737,” Genome Announc., vol. 4, no. 3, p. doi:10.1128/ genomeA.00248-16, 2016.

H. Luna-Flores, R. W. Palfreyman, J. O. Krömer, L. K. Nielsen, and E. Marcellin, “Improved production of propionic acid using genome shuffling,” Biotechnol. J., pp. 1–12, 2016.

C. H. Luna-Flores, J. J. Ramírez-Cordova, C. Pelayo-Ortiz, R. Femat, and E. J. Herrera-López, “Batch and fed-batch modeling of carotenoids production by Xanthophyllomyces dendrorhous using Yucca fillifera date juice as substrate,” Biochem. Eng. J., vol. 53, no. 1, pp. 131–136, 2010.